链脲佐菌素诱导的糖尿病对大鼠膀胱胆碱能运动传递的影响。
The effect of streptozotocin-induced diabetes on cholinergic motor transmission in the rat urinary bladder.
作者信息
Luheshi G N, Zar M A
机构信息
Department of Pharmacological Sciences, Medical School, Newcastle Upon Tyne.
出版信息
Br J Pharmacol. 1991 Jul;103(3):1657-62. doi: 10.1111/j.1476-5381.1991.tb09843.x.
Abstract
- The effect of streptozotocin (STZ)-induced diabetes on cholinergic motor transmission in the rat urinary bladder was investigated by recording contractile activity of detrusor strips in vitro. 2. The Ca(2+)-channel antagonist, nifedipine, was found to be more effective in blocking the noncholinergic motor transmission than P2-purinoceptor desensitization by alpha,beta-methylene ATP. 3. The neurogenic contractile responses to electrical field stimulation in the presence of nifedipine (cholinergic) were larger in the diabetic detrusor than in the non-diabetic controls. The potentiation of the cholinergic transmission was more evident at higher frequencies. 4. Concentration-response curves for acetylcholine were identical in detrusors from diabetic and non-diabetic animals, thus excluding a postsynaptic supersensitivity to acetylcholine being responsible for the potentiation of cholinergic motor transmission. 5. It is concluded that the potentiation of cholinergic motor transmission is due to enhanced release of acetylcholine in diabetic detrusor. Possible reasons for this enhancement are discussed in relation to diabetes.
摘要
- 通过记录体外逼尿肌条的收缩活性，研究了链脲佐菌素（STZ）诱导的糖尿病对大鼠膀胱胆碱能运动传递的影响。2. 发现钙通道拮抗剂硝苯地平在阻断非胆碱能运动传递方面比α,β-亚甲基ATP对P2嘌呤受体的脱敏作用更有效。3. 在硝苯地平存在的情况下（胆碱能），糖尿病逼尿肌对电场刺激的神经源性收缩反应比非糖尿病对照组更大。胆碱能传递的增强在更高频率时更明显。4. 糖尿病和非糖尿病动物逼尿肌中乙酰胆碱的浓度-反应曲线相同，因此排除了对乙酰胆碱的突触后超敏反应是胆碱能运动传递增强的原因。5. 得出结论，胆碱能运动传递的增强是由于糖尿病逼尿肌中乙酰胆碱释放增加所致。并结合糖尿病讨论了这种增强的可能原因。
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