暴饮酒精治疗会增加卵巢切除术后的椎骨骨质流失：通过间歇性甲状旁腺激素进行代偿。
Binge alcohol treatment increases vertebral bone loss following ovariectomy: compensation by intermittent parathyroid hormone.
作者信息
Callaci John J, Juknelis Dainius, Patwardhan Avinash, Wezeman Frederick H
机构信息
Department of Orthopaedic Surgery and Rehabilitation, Loyola University Stritch School of Medicine, Maywood, Illinois 60153, USA.
出版信息
Alcohol Clin Exp Res. 2006 Apr;30(4):665-72. doi: 10.1111/j.1530-0277.2006.00078.x.
BACKGROUND
Postmenopausal estrogen deficiency and alcohol abuse are known risk factors for osteoporosis. Previous studies of the combined effect of alcohol and ovariectomy on bone loss using chronic alcohol-feeding models have not demonstrated additional alcohol-induced bone loss in ovariectomized (OVX) animals. Binge alcohol treatment causes rapid bone loss in male rats. We hypothesized that binge alcohol would cause additional bone loss in OVX rats.
METHODS
Ninety-six adult (400 g) female Sprague-Dawley rats (48 sham-operated and 48 OVX, pair fed) were randomly divided into 4 treatment groups: (a) saline-treated, (b) binge alcohol-treated (3 g/kg alcohol as a 20% weight to volume alcohol/saline solution, intraperitoneal (IP), 3 times per week), (c) parathyroid hormone (PTH)-treated (80 microg/kg, SC, 5 d/wk), and (d) binge alcohol plus PTH. Rats were treated for either 2 or 4 weeks. Following treatment periods, blood was collected for alcohol concentration (BAC) measurements; lumbar vertebrae were removed for bone mineral density (BMD) levels, trabecular microarchitecture assessment, and vertebral compressive strength analysis.
RESULTS
Peak binge BACs averaged 300 mg/dL. Alcohol and OVX decreased cancellous BMD: alcohol and OVX treatment in combination caused additional cancellous BMD loss and significant cortical BMD reductions. Compressive strength was also decreased by OVX and alcohol. Combination treatment resulted in further declines in bone strength. Micro-CT analysis revealed a significant effect of combined OVX and alcohol treatment resulting in decreased trabecular bone volume/total volume (BV/TV). Intermittent PTH administration compensated for losses of BMD, compressive strength, and restored BV/TV deficits caused by OVX, alcohol, or their combination.
CONCLUSIONS
Bone loss following OVX can be significantly increased by concurrent binge alcohol treatment. The effects of alcohol and OVX are compensated by concurrent intermittent treatment with PTH. These results suggest that postmenopausal women who abuse alcohol may place their skeleton at additional risk for osteoporotic fracture.
背景
绝经后雌激素缺乏和酗酒是已知的骨质疏松风险因素。以往使用慢性酒精喂养模型对酒精与卵巢切除术联合作用于骨质流失的研究，并未证明去卵巢（OVX）动物存在额外的酒精性骨质流失。暴饮酒精处理会导致雄性大鼠快速骨质流失。我们假设暴饮酒精会导致OVX大鼠出现额外的骨质流失。
方法
96只成年（400克）雌性Sprague-Dawley大鼠（48只假手术组和48只OVX组，配对饲养）被随机分为4个治疗组：（a）生理盐水处理组，（b）暴饮酒精处理组（以20%重量/体积的酒精/生理盐水溶液腹腔注射（IP）3克/千克酒精，每周3次），（c）甲状旁腺激素（PTH）处理组（80微克/千克，皮下注射，每周5天），以及（d）暴饮酒精加PTH组。大鼠接受2周或4周的治疗。治疗期结束后，采集血液测量酒精浓度（BAC）；取出腰椎进行骨密度（BMD）水平、小梁微结构评估和椎体抗压强度分析。
结果
暴饮酒精后的峰值BAC平均为300毫克/分升。酒精和OVX降低了松质骨BMD：酒精与OVX联合治疗导致额外的松质骨BMD丢失和显著的皮质骨BMD降低。OVX和酒精也降低了抗压强度。联合治疗导致骨强度进一步下降。显微CT分析显示，OVX与酒精联合治疗有显著效果，导致小梁骨体积/总体积（BV/TV）降低。间歇性给予PTH可补偿OVX、酒精或其联合作用导致的BMD、抗压强度损失，并恢复BV/TV缺陷。
结论
同时进行暴饮酒精治疗可显著增加OVX后的骨质流失。酒精和OVX的影响可通过同时进行间歇性PTH治疗得到补偿。这些结果表明，酗酒的绝经后女性可能使其骨骼面临额外的骨质疏松性骨折风险。
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