酒精对骨骼健康、内稳态及骨折修复的影响。
Impact of Alcohol on Bone Health, Homeostasis and Fracture repair.
作者信息
Eby Jonathan M, Sharieh Farah, Callaci John J
机构信息
Department of Orthopaedic Surgery and Rehabilitation, Loyola University Medical Center, Maywood, Illinois.
Alcohol Research Program (ARP), Loyola University Chicago Stritch School of Medicine, Maywood, Illinois 60153, USA.
出版信息
Curr Pathobiol Rep. 2020 Sep;8(3):75-86. doi: 10.1007/s40139-020-00209-7. Epub 2020 Jul 28.
Abstract
PURPOSE OF REVIEW
Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeostasis and fracture repair to highlight what has been learned in people and animal models of alcohol consumption.
RECENT FINDINGS
Recently, forkhead box O (FoxO) has been found to be upregulated and activated in mesenchymal stem cells (MSC) exposed to alcohol. FoxO has also been found to modulate Wnt/β-catenin signaling, which is necessary for MSC differentiation. Recent evidence suggests alcohol activates FoxO signaling, which may be dysregulating Wnt/β-catenin signaling in MSCs cultured in alcohol.
SUMMARY
This review highlights the negative health effects learned from people and chronic and episodic binge alcohol consumption animal models. Studies using chronic alcohol exposure or alcohol exposure then bone fracture repair model have explored several different cellular and molecular signaling pathways important for bone homeostasis and fracture repair, and offer potential for future experiments to explore additional signaling pathways that may be dysregulated by alcohol exposure.
摘要
综述目的
全球范围内酒精使用量持续上升。我们回顾了当前关于酒精对骨骼健康、体内平衡和骨折修复影响的文献，以突出在饮酒人群和动物模型中所了解到的情况。
最新发现
最近发现，在暴露于酒精的间充质干细胞（MSC）中，叉头框O（FoxO）被上调并激活。还发现FoxO可调节Wnt/β-连环蛋白信号传导，而这对MSC分化至关重要。近期证据表明酒精激活了FoxO信号传导，这可能会使在酒精中培养的MSC中的Wnt/β-连环蛋白信号传导失调。
总结
本综述强调了从人群以及慢性和间歇性暴饮酒精消费动物模型中了解到的负面健康影响。使用慢性酒精暴露或酒精暴露后骨折修复模型的研究已经探索了几种对骨骼体内平衡和骨折修复重要的不同细胞和分子信号通路，并为未来实验探索可能因酒精暴露而失调的其他信号通路提供了潜力。
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本文引用的文献
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2
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J Pharmacol Exp Ther. 2020 Jun;373(3):337-346. doi: 10.1124/jpet.119.264374. Epub 2020 Mar 25.
3
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8
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