通过软光刻技术制备用于药物递送的聚合物微粒

Fabrication of polymeric microparticles for drug delivery by soft lithography.

作者信息

Guan Jingjiao, Ferrell Nicholas, James Lee L, Hansford Derek J

机构信息

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

出版信息

Biomaterials. 2006 Jul;27(21):4034-41. doi: 10.1016/j.biomaterials.2006.03.011. Epub 2006 Mar 30.

DOI:10.1016/j.biomaterials.2006.03.011

PMID:16574217

Abstract

Soft lithographic techniques were used to fabricate polymeric microparticles for drug delivery applications. The microparticles were made of thermoplastics and thermosets from different types of precursors including reactive resin and polymer solutions in organic solvents or water. The microparticles produced using these methods were made of widely used polymers for drug delivery with highly uniform sizes, plate-like morphology, and well-defined lateral sizes and shapes, making them potentially useful for drug delivery applications and as platform for the construction of multi-functional drug delivery devices.

摘要

软光刻技术被用于制造用于药物递送应用的聚合物微粒。这些微粒由热塑性塑料和热固性塑料制成，原料来自不同类型的前体，包括反应性树脂以及有机溶剂或水中的聚合物溶液。使用这些方法生产的微粒由广泛用于药物递送的聚合物制成，具有高度均匀的尺寸、片状形态以及明确的横向尺寸和形状，使其在药物递送应用中具有潜在用途，并可作为构建多功能药物递送装置的平台。