Clegg John R, Wagner Angela M, Shin Su Ryon, Hassan Shabir, Khademhosseini Ali, Peppas Nicholas A
Department of Biomedical Engineering, the University of Texas at Austin, Austin, Texas, USA.
McKetta Department of Chemical Engineering, the University of Texas at Austin, Austin, Texas, USA.
Prog Mater Sci. 2019 Dec;106. doi: 10.1016/j.pmatsci.2019.100589. Epub 2019 Jul 17.
One of the goals of biomaterials science is to reverse engineer aspects of human and nonhuman physiology. Similar to the body's regulatory mechanisms, such devices must transduce changes in the physiological environment or the presence of an external stimulus into a detectable or therapeutic response. This review is a comprehensive evaluation and critical analysis of the design and fabrication of environmentally responsive cell-material constructs for bioinspired machinery and biomimetic devices. In a bottom-up analysis, we begin by reviewing fundamental principles that explain materials' responses to chemical gradients, biomarkers, electromagnetic fields, light, and temperature. Strategies for fabricating highly ordered assemblies of material components at the nano to macro-scales via directed assembly, lithography, 3D printing and 4D printing are also presented. We conclude with an account of contemporary material-tissue interfaces within bioinspired and biomimetic devices for peptide delivery, cancer theranostics, biomonitoring, neuroprosthetics, soft robotics, and biological machines.
生物材料科学的目标之一是对人类和非人类生理学的各个方面进行逆向工程。与人体的调节机制类似，此类装置必须将生理环境的变化或外部刺激的存在转化为可检测的或治疗性反应。本综述是对用于生物启发机械和仿生装置的环境响应性细胞-材料构建体的设计与制造的全面评估和批判性分析。在自下而上的分析中，我们首先回顾解释材料对化学梯度、生物标志物、电磁场、光和温度的响应的基本原理。还介绍了通过定向组装、光刻、3D打印和4D打印在纳米到宏观尺度上制造材料组件的高度有序组装体的策略。我们最后阐述了生物启发和仿生装置中用于肽递送、癌症诊疗、生物监测、神经假体、软机器人和生物机器的当代材料-组织界面。
