Ludvigsson Jonas F, Montgomery Scott M, Olén Ola, Ekbom Anders, Ludvigsson Johnny, Fored Michael
Department of Paediatrics, Orebro University Hospital, Sweden.
Nephrol Dial Transplant. 2006 Jul;21(7):1809-15. doi: 10.1093/ndt/gfl117. Epub 2006 Mar 30.
Coeliac disease (CD) may be a risk factor for renal disease.
We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14,336 patients who had received a diagnosis of CD (1964-2003) and 69,875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry.
CD was associated with an increased risk of any form of GN (hazard ratio (HR) = 1.64; 95% confidence intervals (CI) = 1.01-2.66; P = 0.046; 89 events), CGN (HR = 2.65; 95% CI = 1.34-5.24; P = 0.005; 39 events), dialysis (HR = 3.48; 95% CI = 2.26-5.37; P < 0.001; 102 positive events) and KT (HR = 3.15; 95% CI = 1.29-7.71; P = 0.012; 22 events).
We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN.
乳糜泻（CD）可能是肾脏疾病的一个风险因素。
在一项基于普通人群的队列研究中，我们调查了CD患者发生任何形式的肾小球肾炎（GN）（急性、慢性和未明确类型）、慢性肾小球肾炎（CGN）以及包括透析治疗和肾移植（KT）在内的肾脏替代治疗的风险。我们使用Cox回归分析，评估了14336例已确诊为CD的患者（1964 - 2003年）以及69875例按年龄、日历年、性别和郡县匹配的对照个体发生肾脏疾病的风险。患者通过瑞典医院出院登记系统进行识别。随访从研究入组后1年开始。
CD与任何形式的GN风险增加相关（风险比（HR）= 1.64；95%置信区间（CI）= 1.01 - 2.66；P = 0.046；89例事件）、CGN（HR = 2.65；95% CI = 1.34 - 5.24；P = 0.005；39例事件）、透析（HR = 3.48；95% CI = 2.26 - 5.37；P < 0.001；102例阳性事件）和KT（HR = 3.15；95% CI = 1.29 - 7.71；P = 0.012；22例事件）。
我们认为与CD相关的免疫特征会增加慢性肾脏疾病的风险。CD患者发生任何形式GN的风险也可能适度增加。
Zotero 插件