Lehto Markku, Groop Per-Henrik
Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Abdominal Center of Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Front Endocrinol (Lausanne). 2018 Sep 19;9:553. doi: 10.3389/fendo.2018.00553. eCollection 2018.
Diabetic kidney disease (DKD) is a devastating condition associated with increased morbidity and premature mortality. The etiology of DKD is still largely unknown. However, the risk of DKD development and progression is most likely modulated by a combination of genetic and environmental factors. Patients with autoimmune diseases, like type 1 diabetes, inflammatory bowel disease, and celiac disease, share some genetic background. Furthermore, gastrointestinal disorders are associated with an increased risk of kidney disease, although the true mechanisms have still to be elucidated. Therefore, the principal aim of this review is to evaluate the impact of disturbances in the gastrointestinal tract on the development of renal disorders.
糖尿病肾病（DKD）是一种具有高发病率和过早死亡率的严重疾病。DKD的病因在很大程度上仍然未知。然而，DKD发生和进展的风险很可能是由遗传和环境因素共同调节的。患有自身免疫性疾病的患者，如1型糖尿病、炎症性肠病和乳糜泻，具有一些共同的遗传背景。此外，胃肠道疾病与肾脏疾病风险增加有关，尽管其真正机制仍有待阐明。因此，本综述的主要目的是评估胃肠道紊乱对肾脏疾病发展的影响。
