Kennedy Richard E, Kerns Robnet T, Kong Xiangrong, Archer Kellie J, Miles Michael F
Department of Biostatistics, Virginia Commonwealth University Box 980032, Richmond, VA 23298-0032, USA.
Bioinformatics. 2006 May 15;22(10):1272-4. doi: 10.1093/bioinformatics/btl108. Epub 2006 Mar 30.
SScore is an R package that facilitates the comparison of gene expression between Affymetrix GeneChips using the S-score algorithm. The S-score algorithm uses probe level data directly to assess differences in gene expression, without requiring a preliminary separate step of probe set expression summary estimation. Therefore, the algorithm avoids introduction of error associated with the expression summary estimation process and has been demonstrated to improve the accuracy of identifying differentially expressed genes. The S-score produces accurate results even when few or no replicates are available.
The R package SScore is available from Bioconductor at http://www.bioconductor.org
SScore是一个R软件包，它使用S分数算法促进Affymetrix基因芯片之间基因表达的比较。S分数算法直接使用探针水平数据来评估基因表达的差异，无需预先单独进行探针集表达汇总估计步骤。因此，该算法避免了与表达汇总估计过程相关的误差引入，并已被证明可提高识别差异表达基因的准确性。即使在几乎没有或没有重复样本的情况下，S分数也能产生准确的结果。
R软件包SScore可从Bioconductor获取，网址为http://www.bioconductor.org
