有机催化的α,α-二氰基烯烃与α,β-不饱和醛的直接不对称乙烯基迈克尔加成反应。
Organocatalytic and direct asymmetric vinylogous Michael addition of alpha,alpha-dicyanoolefins to alpha,beta-unsaturated aldehydes.
作者信息
Xie Jian-Wu, Yue Lei, Xue Dong, Ma Xiao-Li, Chen Ying-Chun, Wu Yong, Zhu Jin, Deng Jin-Gen
机构信息
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.
出版信息
Chem Commun (Camb). 2006 Apr 14(14):1563-5. doi: 10.1039/b600647g. Epub 2006 Mar 7.
The first highly regio-, chemo-, diastereo- and enantioselective direct vinylogous Michael addition of alpha,alpha-dicyanoolefins to alpha,beta-unsaturated aldehydes is described, employing readily available chiral alpha,alpha-diarylprolinol salts as iminium organocatalysts.
本文描述了首例高度区域选择性、化学选择性、非对映选择性和对映选择性的α,α-二氰基烯烃与α,β-不饱和醛的直接乙烯基迈克尔加成反应，该反应使用易于获得的手性α,α-二芳基脯氨醇盐作为亚胺有机催化剂。
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