Surfing on prothymosin alpha proliferation and anti-apoptotic properties.

Prothymosin alpha is an extremely abundant nuclear oncoprotein-transcription factor essential for cell cycle progression and proliferation that has been recently suggested as an anti- apoptotic factor. Similarly to other oncoproteins, prothymosin alpha is overexpressed in a variety of cancer tissues and cell lines. The present review highlights on the proliferation and anti-apoptotic properties of prothymosin alpha and its possible role in cancer development.