血管内超声射频数据分析的可重复性：对纵向研究设计的启示
Reproducibility of intravascular ultrasound radiofrequency data analysis: implications for the design of longitudinal studies.
作者信息
Rodriguez-Granillo Gastón A, Vaina Sophia, García-García Héctor M, Valgimigli Marco, Duckers Eric, van Geuns Robert J, Regar Evelyn, van der Giessen William J, Bressers Marco, Goedhart Dick, Morel Marie-Angele, de Feyter Pim J, Serruys Patrick W
机构信息
Department of Interventional Cardiology of the Erasmus Medical Center, Rotterdam, The Netherlands.
出版信息
Int J Cardiovasc Imaging. 2006 Oct;22(5):621-31. doi: 10.1007/s10554-006-9080-0. Epub 2006 Mar 31.
OBJECTIVES
The purpose of this study was to assess in vivo the reproducibility of tissue characterization using spectral analysis of intravascular ultrasound (IVUS) radiofrequency data (IVUS-VH).
BACKGROUND
Despite the need for reproducibility data to design longitudinal studies, such information remains unexplored.
METHODS AND RESULTS
IVUS-VH (Volcano Corp., Rancho Cordova, USA) was performed in patients referred for elective percutaneous intervention and in whom a non-intervened vessel was judged suitable for a safe IVUS interrogation. The IVUS catheters used were commercially available catheters (20 MHz, Volcano Corp., Rancho Cordova, USA). Following IVUS-VH acquisition, and after the disengagement and re-engagement of the guiding catheter, an additional acquisition was performed using a new IVUS catheter. Fifteen patients with 16 non-significant lesions were assessed by 2 independent observers. The relative inter-catheter differences regarding geometrical measurements were negligible for both observers. The inter-catheter relative difference in plaque cross-sectional area (CSA) was 3.2% for observer 1 and 0.5% for observer 2. The limits of agreement for (observer 1 measurements) lumen, vessel, plaque and plaque burden measurements were 0.82, -1.10 mm(2); 0.80, -0.66 mm(2); 1.08, -0.66 mm(2); and 5.83, -3.89%; respectively. Limits of agreement for calcium, fibrous, fibrolipidic and necrotic core CSA measurements were 0.22, -0.25 mm(2); 1.02, -0.71 mm(2); 0.61, -0.65 mm(2); and 0.43, -0.38 mm(2) respectively. Regarding the inter-observer agreement, the limits of agreement for lumen, vessel, plaque and plaque burden measurements were 2.61, -2.09 mm(2); 2.20-3.03 mm(2); 1.70, -3.04 mm(2); and 9.16, -16.41%; respectively, and for calcium, fibrous, fibrolipidic and necrotic core measurements of 0.08, -0.09 mm(2); 0.89, -1.28 mm(2); 0.74, -1.06 mm(2); and 0.16, -0.20 mm(2); respectively.
CONCLUSIONS
The present study demonstrates that the geometrical and compositional output of IVUS-VH is acceptably reproducible.
目的
本研究旨在通过血管内超声（IVUS）射频数据的光谱分析（IVUS-VH）在体内评估组织特征的可重复性。
背景
尽管设计纵向研究需要可重复性数据，但此类信息仍未得到探索。
方法与结果
对因择期经皮介入治疗而就诊且被判定有一条未干预血管适合进行安全IVUS检查的患者进行IVUS-VH（美国加州兰乔科尔多瓦市Volcano公司）检查。使用的IVUS导管为市售导管（20MHz，美国加州兰乔科尔多瓦市Volcano公司）。在进行IVUS-VH采集后，以及在撤出和重新插入引导导管后，使用新的IVUS导管进行额外采集。15名患有16处非显著性病变的患者由2名独立观察者进行评估。两名观察者在几何测量方面的导管间相对差异均可忽略不计。观察者1测得的斑块横截面积（CSA）导管间相对差异为3.2%，观察者2为0.5%。（观察者1测量值）管腔、血管、斑块和斑块负荷测量值的一致性界限分别为0.82，-1.10mm²；0.80，-0.66mm²；1.08，-0.66mm²；以及5.83，-3.89%。钙、纤维、纤维脂质和坏死核心CSA测量值的一致性界限分别为0.22，-0.25mm²；1.02，-0.71mm²；0.61，-0.65mm²；以及0.43，-0.38mm²。关于观察者间的一致性，管腔、血管、斑块和斑块负荷测量值的一致性界限分别为2.61，-2.09mm²；2.20 - 3.03mm²；1.70，-3.04mm²；以及9.16，-16.41%；钙、纤维、纤维脂质和坏死核心测量值的一致性界限分别为0.08，-0.09mm²；0.89，-1.28mm²；0.74，-1.06mm²；以及0.16，-0.20mm²。
结论
本研究表明IVUS-VH的几何和成分输出具有可接受的可重复性。
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