Jeske Arthur H
Department of Restorative Dentistry and Biomaterials, University of Texas Dental Branch, Houston, USA.
Tex Dent J. 2006 Feb;123(2):190-7.
Triptan drugs continue to constitute the major pharmacotherapeutic interventional agents for migraine therapy. Interactions of dental drugs with migraine medications are limited, but their seriousness dictates that dentists be aware of the use of ergot alkaloids, triptans, or other migraine drugs. While many migraine sufferers avoid dental therapy dur ing migraine attacks, the practitioner who is treating a patient who has taken migraine medications must carefully monitor the cardiovascular status of the patient, which may affect the use of vasoconstrictors. Macrolide antibiotics and azole antifungals represent additional drug groups that are prescribed by dentists but which may potentiate the adverse effects of migraine drugs. Migraine patients prefer agents that offer rapid onset of relief and total relief within a couple hours of drug administration; they also prefer therapy that prevents recurrences and does not require "rescue" medications, and, of course, a lack of adverse effects and interactions with other medications. Currently, no single drug or class of drugs offers this ideal combination of actions in all patients.
曲坦类药物仍然是偏头痛治疗的主要药物治疗干预剂。牙科药物与偏头痛药物的相互作用有限，但鉴于其严重性，牙医必须了解麦角生物碱、曲坦类药物或其他偏头痛药物的使用情况。虽然许多偏头痛患者在偏头痛发作期间会避免牙科治疗，但治疗服用过偏头痛药物患者的从业者必须仔细监测患者的心血管状况，这可能会影响血管收缩剂的使用。大环内酯类抗生素和唑类抗真菌药是牙医会开具的另外两类药物，但它们可能会增强偏头痛药物的不良反应。偏头痛患者更喜欢在给药后几小时内就能迅速起效并完全缓解的药物；他们也更喜欢能预防复发且不需要“急救”药物的治疗方法，当然，还希望药物没有不良反应且不与其他药物相互作用。目前，没有单一药物或一类药物能在所有患者中提供这种理想的综合作用。
