Perlis Michael L, Smith Leisha J, Lyness Jeffrey M, Matteson Sara R, Pigeon Wil R, Jungquist Carla R, Tu Xin
Department of Psychiatry and UR Neurosciences Program, University of Rochester, NY 14642, USA.
Behav Sleep Med. 2006;4(2):104-13. doi: 10.1207/s15402010bsm0402_3.
There are at least 9 studies that provide evidence that insomnia is a significant risk factor for recurrent and new onset major depressive disorder (MDD), two of which suggest that this association also exists specifically for the elderly. In this study, archival data from a community sample of healthy elderly participants were used to assess the extent to which insomnia predicts future illness in this age cohort. Out of the 147 participants with no prior history of mental illness, 66 participants were classified as having no insomnia, 47 had indeterminate insomnia, and 34 had persistent insomnia. Twelve participants developed MDD during the 1-year follow-up period. Two had no insomnia, 4 had indeterminate insomnia, and 6 had persistent insomnia. Persistent insomnia with onset of depression occurred only in female participants and was significantly associated with middle insomnia. These data suggest that elderly participants with persistent insomnia are at greater risk for the development of new onset depression.
至少有9项研究提供了证据,表明失眠是复发性和新发重度抑郁症(MDD)的一个重要风险因素,其中两项研究表明这种关联在老年人中也特别存在。在本研究中,来自健康老年参与者社区样本的档案数据被用于评估失眠在该年龄队列中预测未来疾病的程度。在147名无精神疾病既往史的参与者中,66名参与者被归类为无失眠,47名有不确定失眠,34名有持续性失眠。在1年的随访期内,12名参与者患上了MDD。2名无失眠,4名有不确定失眠,6名有持续性失眠。伴有抑郁症发作的持续性失眠仅发生在女性参与者中,且与中度失眠显著相关。这些数据表明,患有持续性失眠的老年参与者患新发抑郁症的风险更大。