Simon Ernesto, Camier Sylvie, Séraphin Bertrand
Equipe Labellisée La Ligue, Centre de Génétique Moléculaire, CNRS UPR2167, Avenue de la Terrasse, 91198 Gif-sur-Yvette cedex, France.
Trends Biochem Sci. 2006 May;31(5):241-3. doi: 10.1016/j.tibs.2006.03.001. Epub 2006 Mar 31.
mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression. Resolution of the yeast Dcp2 structure has enabled identification of the residues that are important for its interaction with Dcp1. However, the human decapping machinery seems to be more complex because a third component, Hedls, is required for a functional Dcp1-Dcp2 interaction.
mRNA去帽不可逆地将mRNA靶向快速降解。帽的去除由去帽蛋白Dcp2催化，但也需要Dcp1。最近，两个研究小组首次揭示了基因表达这一关键步骤的调控机制。酵母Dcp2结构的解析使得鉴定出对其与Dcp1相互作用重要的残基成为可能。然而，人类去帽机制似乎更为复杂，因为功能性的Dcp1-Dcp2相互作用还需要第三个组分Hedls。
