Ducibella Tom, Schultz Richard M, Ozil Jean-Pierre
Department of OB/GYN, Tufts-New England Medical Center & Cell, Molecular, and Developmental Biology, Tufts University School of Medicine, Box 36, 750 Washington Street, Boston, MA 02111, USA.
Semin Cell Dev Biol. 2006 Apr;17(2):324-32. doi: 10.1016/j.semcdb.2006.02.010. Epub 2006 Mar 2.
The mammalian egg appears to transduce the duration, amplitude, and temporal presentation of the increase in the intracellular calcium concentration (Ca(2+)) upon fertilization. These Ca(2+) parameters have important short-term effects on the initiation and completion of early events of egg activation, as well as much later consequences for the extent of peri-implantation development. Recent studies have begun to shed light on how the egg quantitatively interprets the Ca(2+) signal (e.g., by summation of individual Ca(2+) rises) and the mechanisms by which down-stream Ca(2+) effectors, such as Ca(2+)/Calmodulin (CaM)-dependent protein kinase II (CaMKII), utilize this ionic signal to promote biological events that initiate development.
哺乳动物的卵子似乎能转导受精时细胞内钙浓度（[Ca(2+)]i）升高的持续时间、幅度和时间呈现。这些钙参数对卵子激活早期事件的启动和完成具有重要的短期影响，对植入前发育程度也有更后期的影响。最近的研究开始揭示卵子如何定量解读钙信号（例如通过单个钙升高的总和），以及下游钙效应器，如钙/钙调蛋白（CaM）依赖性蛋白激酶II（CaMKII）利用这种离子信号促进启动发育的生物学事件的机制。
