Hotz G
Department of Maxillofacial Surgery, University of Heidelberg, Germany.
Int J Oral Maxillofac Surg. 1991 Aug;20(4):204-7. doi: 10.1016/s0901-5027(05)80175-4.
Histological studies in animals have shown that fibrin sealant can be employed as a resorbable, biological binding agent for fixation of initially mouldable hydroxylapatite (HA) implants. Mixing HA granules with a 2 component fibrin sealant from which thrombin solution has been diluted to 1 IU/ml provides a simple method for obtaining mouldable implants. During insertion of the HA granules, the sealant prevents dislocation and migration, and on solidification, the moulded implant securely retains its shape and position until connective tissue ingrowth is complete. The use of polygonal granules permits a constant implant contour from the very beginning.
对动物的组织学研究表明，纤维蛋白密封剂可作为一种可吸收的生物粘合剂，用于固定初始可塑形的羟基磷灰石（HA）植入物。将HA颗粒与已将凝血酶溶液稀释至1 IU/ml的双组分纤维蛋白密封剂混合，提供了一种获得可塑形植入物的简单方法。在植入HA颗粒过程中，密封剂可防止其移位和迁移，固化后，塑形的植入物能牢固保持其形状和位置，直至结缔组织向内生长完成。使用多边形颗粒从一开始就能使植入物轮廓保持恒定。
