cDNA clones of Japanese hepatitis C virus genomes derived from a single patient show sequence heterogeneity.
作者信息
Oshima M, Tsuchiya M, Yagasaki M, Orita T, Hasegawa M, Tomonoh K, Kojima T, Hirata Y, Yamamoto O, Sho Y
机构信息
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, Shizuoka, Japan.
出版信息
J Gen Virol. 1991 Nov;72 ( Pt 11):2805-9. doi: 10.1099/0022-1317-72-11-2805.
PMID:1658209
Abstract
Twelve cDNA clones of Japanese hepatitis C virus (HCV) have been isolated from liver tissue of a single non-A, non-B hepatitis patient. These clones represented the non-structural domains of HCV. The degree of substitution in the nucleotide sequences and deduced amino acid sequences between these clones was 9.5 and 7.7%, respectively. This high level of substitution suggested that repeated infections of different HCVs may have occurred in the patient.
摘要
Zotero 插件