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肝吸虫诱发胆管癌。

Liver fluke induces cholangiocarcinoma.

作者信息

Sripa Banchob, Kaewkes Sasithorn, Sithithaworn Paiboon, Mairiang Eimorn, Laha Thewarach, Smout Michael, Pairojkul Chawalit, Bhudhisawasdi Vajaraphongsa, Tesana Smarn, Thinkamrop Bandit, Bethony Jeffrey M, Loukas Alex, Brindley Paul J

机构信息

Department of Pathology, Khon Kaen University, Khon Kaen, Thailand.

出版信息

PLoS Med. 2007 Jul;4(7):e201. doi: 10.1371/journal.pmed.0040201.

DOI:10.1371/journal.pmed.0040201
PMID:17622191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1913093/
Abstract

The authors discuss the molecular pathogenesis of opisthorchiasis and associated cholangiocarcinogenesis, particularly nitrative and oxidative DNA damage and the clinical manifestations of cholangiocarcinoma.

摘要

作者们讨论了华支睾吸虫病的分子发病机制及相关胆管癌发生机制，尤其是硝化和氧化DNA损伤以及胆管癌的临床表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/40c637da8b5b/pmed.0040201.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/a1fd3a441c00/pmed.0040201.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/db7eae892488/pmed.0040201.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/f67acec4c2f5/pmed.0040201.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/d8d8013ad219/pmed.0040201.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/40c637da8b5b/pmed.0040201.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/a1fd3a441c00/pmed.0040201.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/db7eae892488/pmed.0040201.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/f67acec4c2f5/pmed.0040201.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/d8d8013ad219/pmed.0040201.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1fc8/1950196/40c637da8b5b/pmed.0040201.g005.jpg

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本文引用的文献

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Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma.华支睾吸虫与非华支睾吸虫相关的人类肝内胆管癌之间的基因表达谱比较。
Hepatology. 2006 Oct;44(4):1025-38. doi: 10.1002/hep.21330.
2
Gene expression profiling defined pathways correlated with fibroblast cell proliferation induced by Opisthorchis viverrini excretory/secretory product.基因表达谱分析确定了与华支睾吸虫排泄/分泌产物诱导的成纤维细胞增殖相关的信号通路。
World J Gastroenterol. 2006 Jun 14;12(22):3585-92. doi: 10.3748/wjg.v12.i22.3585.
3
Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation.
Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021.
1990年至2021年早发性胆囊癌和胆管癌的全球负担
BMC Gastroenterol. 2025 Jul 1;25(1):461. doi: 10.1186/s12876-025-04080-x.
4
Predicting cisplatin response in cholangiocarcinoma patients using chromosome pattern and related gene expression.利用染色体模式和相关基因表达预测胆管癌患者对顺铂的反应。
Sci Rep. 2025 Jul 1;15(1):20420. doi: 10.1038/s41598-025-06851-8.
5
Comparison of spatial prediction models from Machine Learning of cholangiocarcinoma incidence in Thailand.泰国胆管癌发病率机器学习空间预测模型的比较
BMC Public Health. 2025 Jun 7;25(1):2137. doi: 10.1186/s12889-025-23119-y.
6
Gallbladder and biliary tract cancer burdens in China from 1990 to 2021 and projection to 2044: findings from the 2021 Global Burden of Disease study.1990年至2021年中国胆囊和胆道癌负担及到2044年的预测：2021年全球疾病负担研究的结果
Front Med (Lausanne). 2025 May 9;12:1592621. doi: 10.3389/fmed.2025.1592621. eCollection 2025.
7
Establishing a predictive model for liver fluke infection on the basis of early changes in laboratory indicators: a retrospective study.基于实验室指标早期变化建立肝吸虫感染预测模型：一项回顾性研究
Parasit Vectors. 2025 May 22;18(1):186. doi: 10.1186/s13071-025-06833-9.
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Proteomic profiling reveals common and region-specific protein signatures underlying tumor heterogeneity in cholangiocarcinoma.蛋白质组学分析揭示了胆管癌肿瘤异质性背后的共同和区域特异性蛋白质特征。
Sci Rep. 2025 May 18;15(1):17228. doi: 10.1038/s41598-025-02713-5.
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Melatonin attenuates Helicobacter pylori-mediated cholangiocarcinoma-associated fibroblast activation via modulating integrin/FAK signaling pathway.褪黑素通过调节整合素/黏着斑激酶信号通路减轻幽门螺杆菌介导的胆管癌相关成纤维细胞激活。
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Antioxid Redox Signal. 2006 May-Jun;8(5-6):1033-45. doi: 10.1089/ars.2006.8.1033.
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8
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Mixed infections with Opisthorchis viverrini and intestinal flukes in residents of Vientiane Municipality and Saravane Province in Laos.老挝万象市和沙拉湾省居民感染麝猫后睾吸虫和肠吸虫的混合感染情况。
J Helminthol. 2005 Sep;79(3):283-9. doi: 10.1079/joh2005302.
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J Helminthol. 2005 Sep;79(3):269-81. doi: 10.1079/joh2005300.