Graham Sharon M, McCullough Louise D, Murphy Stephanie J
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
Comp Med. 2004 Oct;54(5):486-96.
Animal models of ischemic stroke are examples of an induced model that can present challenges from the perspectives of protocol review and animal management. The review presented here will include a brief summary of the current state of knowledge about clinical stroke; a general synopsis of important unanswered research questions that justify use of animal stroke models; an overview of various animal models of ischemic stroke, including strengths and limitations; and a discussion of animal care issues relative to ischemic stroke models. Good communication and interactive education among primary investigators, laboratory animal veterinarians and caretakers, and institutional animal care and use committee members are critical in achieving a balance between research objectives and animal care issues when using animal stroke models.
缺血性中风的动物模型是一种诱导模型，从方案审查和动物管理的角度来看可能会带来挑战。本文的综述将包括对临床中风当前知识状态的简要总结；对证明使用动物中风模型合理性的重要未解决研究问题的总体概述；对各种缺血性中风动物模型的概述，包括其优势和局限性；以及对与缺血性中风模型相关的动物护理问题的讨论。在使用动物中风模型时，主要研究者、实验动物兽医和饲养员以及机构动物护理和使用委员会成员之间良好的沟通和互动教育对于在研究目标和动物护理问题之间取得平衡至关重要。
