在海马体长期增强过程中天然缺乏GluR2的AMPA受体的短暂掺入。
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation.
作者信息
Plant Karen, Pelkey Kenneth A, Bortolotto Zuner A, Morita Daiju, Terashima Akira, McBain Chris J, Collingridge Graham L, Isaac John T R
机构信息
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK.
出版信息
Nat Neurosci. 2006 May;9(5):602-4. doi: 10.1038/nn1678. Epub 2006 Apr 2.
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
通常认为，在生理条件下，出生后谷氨酸能主神经元突触仅表达含GluR2的钙不渗透性（CI）α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPAR）。然而，我们在此证明，海马体CA1区锥体神经元中的长时程增强（LTP）会导致缺乏GluR2的钙渗透性（CP）-AMPAR快速整合：CP-AMPAR短暂存在，在LTP诱导后约25分钟被含GluR2的AMPAR取代。因此，CP-AMPAR在LTP期间在CA1锥体细胞突触处生理性表达，并且可能是LTP巩固所必需的。
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