Lukhanina E P, Karaban' I N, Burenok Yu A, Mel'nik N A, Berezetskaya N M
AA Bogomolets Institute of Physiology, Kiev, Ukraine.
Neurosci Behav Physiol. 2006 May;36(4):359-65. doi: 10.1007/s11055-006-0025-9.
The question of the relationship between contingent negative variation and the mechanisms controlling motor and mental functions has received inadequate study. The aims of the present work were to investigate the relationship between the early and late phases of contingent negative variation and the state of motor and mental functions in patients with Parkinson's disease and to study the effects of levodopa on contingent negative variation. Patients with Parkinson's disease showed significant decreases in the amplitudes and areas of both phases of contingent negative variation as compared with subjects of similar age. Correlation analysis demonstrated a negative relationship between the extent of impairment of coordinatory muscle interactions and the amplitudes of both phases of this variation (p < 0.01). There was a positive relationship between the magnitudes of both phases and the state of mental functions, particularly memory (p < 0.05). Treatment of patients with Parkinson's disease with levodopa was followed by a significant increase in the late phase (p < 0.05). The results obtained here provide evidence for the important role of structures supporting both direct motor control and mental functions in forming both phases of contingent negative variation. The greater effect of levodopa on the late phase of contingent negative variation suggests that the efferent system of the basal ganglia has a greater role in generating the late phase than in organizing the early phase of the variation.
关联性负变与控制运动和心理功能机制之间的关系问题尚未得到充分研究。本研究的目的是调查帕金森病患者关联性负变的早期和晚期阶段与运动和心理功能状态之间的关系，并研究左旋多巴对关联性负变的影响。与年龄相仿的受试者相比，帕金森病患者关联性负变两个阶段的波幅和面积均显著降低。相关性分析表明，协调性肌肉相互作用的受损程度与该变化两个阶段的波幅之间呈负相关（p < 0.01）。两个阶段的波幅大小与心理功能状态，尤其是记忆，呈正相关（p < 0.05）。帕金森病患者接受左旋多巴治疗后，晚期波幅显著增加（p < 0.05）。此处获得的结果证明，支持直接运动控制和心理功能的结构在形成关联性负变的两个阶段中发挥重要作用。左旋多巴对关联性负变晚期的影响更大，这表明基底神经节的传出系统在产生关联性负变晚期阶段中比在组织早期阶段中发挥更大作用。
