Levine G M, Rosenthal J
Division of Gastroenterology & Nutrition, Albert Einstein Medical Center, Philadelphia, PA 19141.
JPEN J Parenter Enteral Nutr. 1991 Sep-Oct;15(5):526-9. doi: 10.1177/0148607191015005526.
Dietary fiber plays a role in maintaining colonic structure and function. Recently, fiber-supplemented liquid diets containing primarily soy polysaccharide have been marketed. However, the effects of these diets on the colon, particularly absorptive function, are not well documented. We compared Jevity (containing 1.4% soy polysaccharide) to fiber-free Osmolite. In addition, we were interested in comparing the effects of soy polysaccharide to that of pectin, which has previously been shown to facilitate adaptation. A 1% pectin-supplemented rat liquid diet was compared to the liquid diet alone. After 2 weeks of dietary treatment, rats were anesthetized and in vivo colonic absorption measured. Both Jevity and the pectin-containing diets led to a significantly greater (p less than 0.01) basal and butyrate stimulated water absorption as well as 20 mM butyrate absorption compared to their fiber-free fed controls. After perfusion, rats were killed and parameters of colonic mass measured including mucosal weight, protein, and DNA. The fiber-containing diets produced a modest, nonsignificantly greater colonic mass compared to their fiber-free controls. A commercial diet containing soy polysaccharide seems to be equally effective as pectin in maintaining colonic absorptive function.
膳食纤维在维持结肠结构和功能方面发挥着作用。最近，主要含有大豆多糖的补充纤维的流食已上市销售。然而，这些流食对结肠的影响，尤其是吸收功能，尚未得到充分记录。我们将能全力佳（含有1.4%大豆多糖）与不含纤维的能全素进行了比较。此外，我们还对比较大豆多糖与果胶的效果感兴趣，此前已表明果胶有助于适应性调节。将补充1%果胶的大鼠流食与单纯流食进行比较。经过2周的饮食治疗后，对大鼠实施麻醉并测量体内结肠吸收情况。与不含纤维的对照饮食相比，能全力佳和含果胶的饮食均导致基础和丁酸盐刺激的水吸收以及20 mM丁酸盐吸收显著增加（p小于0.01）。灌注后，处死大鼠并测量结肠质量参数，包括黏膜重量、蛋白质和DNA。与不含纤维的对照饮食相比，含纤维的饮食使结肠质量略有增加，但无显著差异。一种含有大豆多糖的商业饮食在维持结肠吸收功能方面似乎与果胶同样有效。
