Friedel D, Levine G M
Division of Gastroenterology and Nutrition, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141.
JPEN J Parenter Enteral Nutr. 1992 Jan-Feb;16(1):1-4. doi: 10.1177/014860719201600101.
Short-chain fatty acids (SCFA), fermentation products of fiber, are believed to play a role in intestinal adaptation. Although the administration of fiber or the infusion of SCFA has been shown to cause colonic growth, studies have been done primarily in enterally fed animals. In addition, the effects of SCFA on absorptive function have not been determined. Adult male rats were maintained on total parenteral nutrition (TPN) and, in addition, received either 150 mmol/L of saline or 150 mmol/L of SCFA mixture (60:25:15, acetate:propionate:butyrate) into the proximal colon. One week later, the in vivo absorption of water, electrolytes, and 20 mmol/L of butyrate was measured. After the rats were killed, parameters of colonic mass were determined. SCFA infusion into the colon had no significant effect on absorptive function. However, significantly greater mucosal height (p less than .01) and mucosal DNA (p less than .05), were observed. Although SCFA has a modest effect on colonic structure, they do not influence absorptive function in TPN rats.
短链脂肪酸（SCFA）是纤维的发酵产物，被认为在肠道适应过程中发挥作用。尽管已证明给予纤维或输注SCFA会导致结肠生长，但相关研究主要是在经肠喂养的动物身上进行的。此外，SCFA对吸收功能的影响尚未确定。成年雄性大鼠维持全肠外营养（TPN），此外，向近端结肠内注入150 mmol/L的生理盐水或150 mmol/L的SCFA混合物（60:25:15，乙酸盐:丙酸盐:丁酸盐）。一周后，测量水、电解质和20 mmol/L丁酸盐的体内吸收情况。处死大鼠后，测定结肠质量参数。向结肠内输注SCFA对吸收功能无显著影响。然而，观察到黏膜高度（p小于0.01）和黏膜DNA（p小于0.05）显著增加。尽管SCFA对结肠结构有一定影响，但它们不会影响TPN大鼠的吸收功能。
