血液相容性碳纳米管——基于纳米的新蛋白聚糖
Blood compatible carbon nanotubes--nano-based neoproteoglycans.
作者信息
Murugesan Saravanababu, Park Tae-Joon, Yang Hoichang, Mousa Shaker, Linhardt Robert J
机构信息
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
出版信息
Langmuir. 2006 Apr 11;22(8):3461-3. doi: 10.1021/la0534468.
Abstract
Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance the blood compatibility of nanomaterials.
摘要
尽管纳米技术已为体内医学应用提供了种类丰富的纳米材料（1-100纳米），但所有这些纳米生物材料的血液相容性在很大程度上仍未得到检验。在此，我们报告了具有血液相容性的碳纳米管（CNT）的制备，这些碳纳米管可能代表了具有体内应用的纳米器件的构建单元。活化部分凝血活酶时间（APTT）和血栓弹力图（TEG）研究证明，肝素化可显著提高纳米材料的血液相容性。
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