纳米生物技术在药物发现中的作用。

The role of nanobiotechnology in drug discovery.

机构信息

Jain PharmaBiotech, Blaesiring 7, CH-4057, Basel, Switzerland.

出版信息

Adv Exp Med Biol. 2009;655:37-43. doi: 10.1007/978-1-4419-1132-2_4.

PMID:20047033

Abstract

The potential applications of nanotechnology in life sciences, particularly nanobiotechnology, include those for drug discovery. This chapter shows how several of the nanotechnologies including nanoparticles and various nanodevices such as nanobiosensors and nanobiochips are being used to improve drug discovery. Nanoscale assays using nanoliter volumes contribute to cost saving. Some nanosubstances such as fullerenes are drug candidates. There are some safety concerns about the in vivo use of nanoparticles that are being investigated. However, future prospects for applications in healthcare of drugs discovered through nanotechnology and their role in the development of personalized medicine appear to be excellent.

摘要

纳米技术在生命科学中的潜在应用，特别是纳米生物技术，包括药物发现。本章展示了包括纳米粒子和各种纳米器件（如纳米生物传感器和纳米生物芯片）在内的几种纳米技术如何被用于改进药物发现。使用纳升级体积的纳米级检测有助于节省成本。一些纳米物质，如富勒烯，是药物候选物。关于体内使用纳米粒子的一些安全问题正在研究中。然而，通过纳米技术发现的药物在医疗保健中的应用以及它们在个性化医学发展中的作用的未来前景似乎非常乐观。