Wiersbitzky S, Abel E, Bruns R, Eberle J, Ladstätter L, Wiersbitzky H, Paul W, Deinhardt F
Klinik und Poliklinik für Kinder- und Jugendmedizin, Ernst-Moritz-Arndt-Universität Greifswald.
Kinderarztl Prax. 1991 Sep;59(9):258-61.
Exanthema subitum was described in 1910 by John Zahorsky/USA; in 1986 and 1988 the human herpesvirus 6 (HHV 6) was discovered as the causative agent of the disease and serologic tests were established for diagnostics (specific IgM and IgG antibodies). Up to this time the diagnosis was based on the typical clinical course: the prodromal febrile stage (3 days) followed by the onset of a (more or less characteristic) rash closely connected with the normalisation of the body temperature. Usually a typical white blood cell count was described for diagnostics on the first day of exanthema: leukocytopenia with eosino- and granulocytopenia associated with consequent lymphocytosis. We analysed the hematologic data for children with a serologically documented HHV6 infection including exanthema (group 1: n = 9), without exanthema (group 2: n = 11) or with a serologically unexplained febrile rash (group 3: n = 13). In children with exanthematous HHV6 infection (exanthema subitum) granulocytopenia and a decreased thrombocyte count (mean values) is the rule. But the total white blood cell count and the mean values for eosinophils did not differ between the groups studied.
幼儿急疹于1910年由美国的约翰·扎霍尔斯基首次描述；1986年和1988年，人类疱疹病毒6型（HHV - 6）被发现是该病的病原体，并建立了血清学检测方法用于诊断（特异性IgM和IgG抗体）。在此之前，诊断是基于典型的临床病程：前驱发热期（3天），随后出现与体温恢复正常密切相关的（或多或少具有特征性的）皮疹。通常在幼儿急疹第一天进行诊断时会描述典型的白细胞计数：白细胞减少伴嗜酸性粒细胞和粒细胞减少，随之出现淋巴细胞增多。我们分析了血清学确诊为HHV6感染的儿童的血液学数据，这些儿童包括患有幼儿急疹的（第1组：n = 9）、未患幼儿急疹的（第2组：n = 11）或患有血清学无法解释的发热性皮疹的（第3组：n = 13）。在患有幼儿急疹样HHV6感染（幼儿急疹）的儿童中，粒细胞减少和血小板计数降低（平均值）是常见情况。但在所研究的各组之间，白细胞总数和嗜酸性粒细胞的平均值并无差异。
