Braito A, Uberti M
Istituto di Clinica delle Malattie Infettive, Università di Siena.
Minerva Pediatr. 1994 Sep;46(9):371-5.
Seventy-five children aged less than 3 yrs, affected by Roseola infantum (maculopapular rash following an acute onset illness characterized by high fever for 2-5 days) were included in this study, 40% of them were admitted with urgency to our clinic for febrile convulsions. Several bacterial or viral agents other than HHV6 were isolated from more than 10% of the children; the role of HHV6 was studied with an immunofluorescence test (IFA) for specific antibodies (seroconversion); 25 single serum samples of the acute phase and 30 acute and convalescent paired sera were available; high positivity was shown in three preexanthematous samples; a serological evidence of HHV6 infection was obtained in only 9 of the 30 paired sera; a coinfection was shown in two subjects belonging to the last group; viral or bacterial agents other than HHV6, were demonstrated in 4 seronegative children. In our experience, the etiologic role of HHV6 in exanthema subitum is not always confirmed; we cannot explain the controversy of our results compared with those of Japanese literature.
本研究纳入了75名3岁以下患幼儿急疹（急性起病，高热2 - 5天，随后出现斑丘疹）的儿童，其中40%因热性惊厥紧急入住我们的诊所。超过10%的儿童分离出了除HHV6之外的几种细菌或病毒病原体；通过免疫荧光试验（IFA）检测特异性抗体（血清转化）来研究HHV6的作用；有25份急性期单份血清样本以及30份急性期和恢复期配对血清样本；3份出疹前样本显示高阳性；30份配对血清中只有9份获得了HHV6感染的血清学证据；最后一组中有2名受试者显示有合并感染；4名血清阴性儿童检测出了除HHV6之外的病毒或细菌病原体。根据我们的经验，HHV6在幼儿急疹中的病因学作用并不总是能得到证实；我们无法解释与日本文献结果相比，我们的结果为何存在争议。
