四亚甲基二砜四胺：一种γ-氨基丁酸诱导的大鼠离体颈上神经节去极化的抑制剂。
Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.
作者信息
Bowery N G, Brown D A, Collins J F
出版信息
Br J Pharmacol. 1975 Mar;53(3):422-4. doi: 10.1111/j.1476-5381.1975.tb07379.x.
Abstract
Tetramethylenedisulphotetramine (TETS), a potent convulsant, antagonized the depolarizing action gamma-aminobutyric acid (GABA) in the isolated superior cervical ganglion of the rat. No antagonism of responses to the cholinomimetic agent carbachol was observed. TETS appeared to act in a non-competitive manner and was reversible. Its activity profile was comparable to that of bicuculline in the same tissue except that the latter appears to act in a competitive manner.
摘要
四亚甲基二砜四胺（毒鼠强）是一种强效惊厥剂，可拮抗大鼠离体颈上神经节中γ-氨基丁酸（GABA）的去极化作用。未观察到其对拟胆碱药卡巴胆碱反应的拮抗作用。毒鼠强似乎以非竞争性方式起作用，且作用是可逆的。除了后者似乎以竞争性方式起作用外，其活性特征与同一组织中荷包牡丹碱的活性特征相当。
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