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四亚甲基二砜四胺：一种γ-氨基丁酸诱导的大鼠离体颈上神经节去极化的抑制剂。

Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.

作者信息

Bowery N G, Brown D A, Collins J F

出版信息

Br J Pharmacol. 1975 Mar;53(3):422-4. doi: 10.1111/j.1476-5381.1975.tb07379.x.

DOI:10.1111/j.1476-5381.1975.tb07379.x
PMID:165847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666460/
Abstract

Tetramethylenedisulphotetramine (TETS), a potent convulsant, antagonized the depolarizing action gamma-aminobutyric acid (GABA) in the isolated superior cervical ganglion of the rat. No antagonism of responses to the cholinomimetic agent carbachol was observed. TETS appeared to act in a non-competitive manner and was reversible. Its activity profile was comparable to that of bicuculline in the same tissue except that the latter appears to act in a competitive manner.

摘要

四亚甲基二砜四胺（毒鼠强）是一种强效惊厥剂，可拮抗大鼠离体颈上神经节中γ-氨基丁酸（GABA）的去极化作用。未观察到其对拟胆碱药卡巴胆碱反应的拮抗作用。毒鼠强似乎以非竞争性方式起作用，且作用是可逆的。除了后者似乎以竞争性方式起作用外，其活性特征与同一组织中荷包牡丹碱的活性特征相当。

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1
Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.四亚甲基二砜四胺：一种γ-氨基丁酸诱导的大鼠离体颈上神经节去极化的抑制剂。
Br J Pharmacol. 1975 Mar;53(3):422-4. doi: 10.1111/j.1476-5381.1975.tb07379.x.
2
A comparison of gamma-aminobutyric acid and the semi-rigid analogues 4-aminotetrolic acid, 4-aminocrotonic acid and imidazole-4-acetic acid on the isolated superior cervical ganglion of the rat.γ-氨基丁酸与半刚性类似物4-氨基四氢吡咯酸、4-氨基巴豆酸和咪唑-4-乙酸对大鼠离体颈上神经节作用的比较
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3
Reversal of the action of amino acid antagonists by barbiturates and other hypnotic drugs.巴比妥类药物及其他催眠药物对氨基酸拮抗剂作用的逆转。
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4
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本文引用的文献

1
Reduction of tetramine toxicity by sedatives and anticonvulsants.镇静剂和抗惊厥药降低毒鼠强毒性的作用。
J Pharm Sci. 1961 Oct;50:858-60. doi: 10.1002/jps.2600501014.
2
The effects of bicuculline and GABA on the superior cervical ganglion of the cat.
Brain Res. 1971 Feb 5;25(3):665-8. doi: 10.1016/0006-8993(71)90473-2.
3
Action of -aminobutyric acid (GABA) on rat sympathetic ganglion cells.γ-氨基丁酸（GABA）对大鼠交感神经节细胞的作用。
Br J Pharmacol. 1973 Mar;47(3):639P-640P.
4
Autoradiographic localization of sites of (3H)gamma-aminobutyric acid accumulation in peripheral autonomic ganglia.外周自主神经节中（3H）γ-氨基丁酸积累位点的放射自显影定位。
Brain Res. 1973 Dec 7;63:479-86. doi: 10.1016/0006-8993(73)90128-5.
5
Bicuculline methochloride as a GABA antagonist.甲基荷包牡丹碱作为一种γ-氨基丁酸拮抗剂。
Nat New Biol. 1972 Dec 13;240(102):219-20. doi: 10.1038/newbio240219a0.
6
-Aminobutyric acid uptake by sympathetic ganglia.交感神经节对γ-氨基丁酸的摄取
Nat New Biol. 1972 Jul 19;238(81):89-91. doi: 10.1038/newbio238089a0.
7
The actions of gamma-aminobutyric acid and related amino acids on mammalian autonomic ganglia.γ-氨基丁酸及相关氨基酸对哺乳动物自主神经节的作用。
J Pharmacol Exp Ther. 1970 Apr;172(2):384-96.
8
Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro.γ-氨基丁酸及相关化合物对大鼠颈上神经节的去极化作用（体外实验）
Br J Pharmacol. 1974 Feb;50(2):205-18. doi: 10.1111/j.1476-5381.1974.tb08563.x.
9
Amino acid transmitters in the mammalian central nervous system.哺乳动物中枢神经系统中的氨基酸递质。
Ergeb Physiol. 1974;69(0):97-188. doi: 10.1007/3-540-06498-2_3.