四亚甲基二砜四胺：一种γ-氨基丁酸诱导的大鼠离体颈上神经节去极化的抑制剂。
Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.
作者信息
Bowery N G, Brown D A, Collins J F
出版信息
Br J Pharmacol. 1975 Mar;53(3):422-4. doi: 10.1111/j.1476-5381.1975.tb07379.x.
Abstract
Tetramethylenedisulphotetramine (TETS), a potent convulsant, antagonized the depolarizing action gamma-aminobutyric acid (GABA) in the isolated superior cervical ganglion of the rat. No antagonism of responses to the cholinomimetic agent carbachol was observed. TETS appeared to act in a non-competitive manner and was reversible. Its activity profile was comparable to that of bicuculline in the same tissue except that the latter appears to act in a competitive manner.
摘要
四亚甲基二砜四胺（毒鼠强）是一种强效惊厥剂，可拮抗大鼠离体颈上神经节中γ-氨基丁酸（GABA）的去极化作用。未观察到其对拟胆碱药卡巴胆碱反应的拮抗作用。毒鼠强似乎以非竞争性方式起作用，且作用是可逆的。除了后者似乎以竞争性方式起作用外，其活性特征与同一组织中荷包牡丹碱的活性特征相当。
相似文献
1
Tetramethylenedisulphotetramine: an inhibitor of gamma-aminobutyric acid induced depolarization of the isolated superior cervical ganglion of the rat.
Br J Pharmacol. 1975 Mar;53(3):422-4. doi: 10.1111/j.1476-5381.1975.tb07379.x.
2
A comparison of gamma-aminobutyric acid and the semi-rigid analogues 4-aminotetrolic acid, 4-aminocrotonic acid and imidazole-4-acetic acid on the isolated superior cervical ganglion of the rat.
Br J Pharmacol. 1976 Mar;56(3):323-30. doi: 10.1111/j.1476-5381.1976.tb07646.x.
3
Reversal of the action of amino acid antagonists by barbiturates and other hypnotic drugs.
Br J Pharmacol. 1978 May;63(1):197-215. doi: 10.1111/j.1476-5381.1978.tb07790.x.
4
5
Effect of tetramethylenedisulphotetramine on the membrane conductance increase produced by gamma-amino-butyric acid at the crab neuromuscular junction.
Br J Pharmacol. 1975 Apr;53(4):598-9. doi: 10.1111/j.1476-5381.1975.tb07401.x.
6
Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord.
Science. 1972 Jan 21;175(4019):331-3. doi: 10.1126/science.175.4019.331.
7
Tetramethylenedisulphotetramine and amino acid inhibition in the rat brain.
Neuropharmacology. 1975 Sep;14(9):703-5. doi: 10.1016/0028-3908(75)90094-5.
8
Presynaptic actions of gamma-aminobutyric acid and some antagonists in a slice preparation of cuneate nucleus.
Br J Pharmacol. 1978 Jul;63(3):495-502. doi: 10.1111/j.1476-5381.1978.tb07803.x.
9
Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro.
Br J Pharmacol. 1974 Feb;50(2):205-18. doi: 10.1111/j.1476-5381.1974.tb08563.x.
10
Agonism and antagonism of gamma-aminobutyric acid.
Nature. 1975 Aug 14;256(5518):600-2. doi: 10.1038/256600a0.
引用本文的文献
1
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Pharmacol Rep. 2023 Feb;75(1):177-188. doi: 10.1007/s43440-022-00437-1. Epub 2022 Nov 23.
2
Tetramethylenedisulfotetramine neurotoxicity: What have we learned in the past 70 years?
Neurobiol Dis. 2020 Jan;133:104491. doi: 10.1016/j.nbd.2019.104491. Epub 2019 Jun 6.
3
GABA receptor: Positive and negative allosteric modulators.
Neuropharmacology. 2018 Jul 1;136(Pt A):10-22. doi: 10.1016/j.neuropharm.2018.01.036. Epub 2018 Jan 31.
4
GABA receptor subtype selectivity of the proconvulsant rodenticide TETS.
Arch Toxicol. 2018 Feb;92(2):833-844. doi: 10.1007/s00204-017-2089-4. Epub 2017 Oct 16.
5
Behavioral intoxication following voluntary oral ingestion of tetramethylenedisulfotetramine: Dose-dependent onset, severity, survival, and recovery.
Neurotoxicology. 2017 Dec;63:21-32. doi: 10.1016/j.neuro.2017.08.009. Epub 2017 Sep 7.
6
Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine.
Anal Chem. 2017 May 16;89(10):5612-5619. doi: 10.1021/acs.analchem.7b00846. Epub 2017 Apr 24.
7
Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents.
Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28.
8
Tetramethylenedisulfotetramine: pest control gone awry.
Ann N Y Acad Sci. 2016 Aug;1378(1):68-79. doi: 10.1111/nyas.13120. Epub 2016 Jul 6.
9
GABAA receptor target of tetramethylenedisulfotetramine.
Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8607-12. doi: 10.1073/pnas.1407379111. Epub 2014 May 27.
10
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
Toxicol Sci. 2012 Dec;130(2):362-72. doi: 10.1093/toxsci/kfs244. Epub 2012 Aug 13.
本文引用的文献
1
Reduction of tetramine toxicity by sedatives and anticonvulsants.
J Pharm Sci. 1961 Oct;50:858-60. doi: 10.1002/jps.2600501014.
2
The effects of bicuculline and GABA on the superior cervical ganglion of the cat.
Brain Res. 1971 Feb 5;25(3):665-8. doi: 10.1016/0006-8993(71)90473-2.
3
Action of -aminobutyric acid (GABA) on rat sympathetic ganglion cells.
Br J Pharmacol. 1973 Mar;47(3):639P-640P.
4
Autoradiographic localization of sites of (3H)gamma-aminobutyric acid accumulation in peripheral autonomic ganglia.
Brain Res. 1973 Dec 7;63:479-86. doi: 10.1016/0006-8993(73)90128-5.
5
Bicuculline methochloride as a GABA antagonist.
Nat New Biol. 1972 Dec 13;240(102):219-20. doi: 10.1038/newbio240219a0.
6
-Aminobutyric acid uptake by sympathetic ganglia.
Nat New Biol. 1972 Jul 19;238(81):89-91. doi: 10.1038/newbio238089a0.
7
The actions of gamma-aminobutyric acid and related amino acids on mammalian autonomic ganglia.
J Pharmacol Exp Ther. 1970 Apr;172(2):384-96.
8
Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro.
Br J Pharmacol. 1974 Feb;50(2):205-18. doi: 10.1111/j.1476-5381.1974.tb08563.x.
9
Amino acid transmitters in the mammalian central nervous system.
Ergeb Physiol. 1974;69(0):97-188. doi: 10.1007/3-540-06498-2_3.
Zotero 插件