Cassar J, Polak J M, Cooke W M
Br J Surg. 1975 Apr;62(4):313-6. doi: 10.1002/bjs.1800620416.
After removal of two large pancreactic insulinomas, although the presenting spontaneous hypoglycaemia was eliminated, severe and persisting haematemesis and melaena supervened with a rise in serum gastrin. The patient had multiple endocrine adenopathy (pituitary, parathyroids and islet cells), but no evidence of a pancreatic gastrin-producing tumour. After emergency gastric operation for the bleeding, the serum gastrin remained high until the hypercalcaemia and hyperparathyroidism had been corrected by subtotal parathyroidectomy. Immunofluorescence studies showed gastrin in the parathyroid tissue.
切除两个大的胰腺胰岛素瘤后，尽管原本出现的自发性低血糖症消除了，但严重且持续的呕血和黑便接踵而至，同时血清胃泌素升高。该患者患有多发性内分泌腺病（垂体、甲状旁腺和胰岛细胞），但没有证据表明存在产生胃泌素的胰腺肿瘤。因出血进行紧急胃部手术后，血清胃泌素一直居高不下，直到甲状旁腺次全切除纠正了高钙血症和甲状旁腺功能亢进。免疫荧光研究显示甲状旁腺组织中有胃泌素。
