Warne G L, Adie R, Hansky J, Martin F I, Varigos G
Aust N Z J Med. 1975 Oct;5(5):466-8. doi: 10.1111/j.1445-5994.1975.tb03059.x.
L-asparaginase (140,000 units) infused into the hepatic artery resulted in a remission from disabling hypoglycaemia for nine months in a man with islet cell carcinoma of the pancreas and hepatic metastases. The tumour produced insulin and gastrin with resulting hypoglycaemia and recurrent peptic ulceration which were unresponsive to other drugs. Following L-asparaginase there was a fall in both plasma and insulin and gastrin.
将140,000单位的L-天冬酰胺酶注入肝动脉后，一名患有胰岛细胞癌并伴有肝转移的男性患者的严重低血糖症状缓解了九个月。该肿瘤分泌胰岛素和胃泌素，导致低血糖和复发性消化性溃疡，而其他药物对此均无反应。使用L-天冬酰胺酶后，血浆、胰岛素和胃泌素水平均下降。
