多肽YY（PYY）对大鼠肾上腺皮质细胞的急性作用：体内与体外效应
Acute action of polypeptide YY (PYY) on rat adrenocortical cells: in vivo versus in vitro effects.
作者信息
Neri G, Andreis P G, Malendowicz L K, Nussdorfer G G
机构信息
Department of Anatomy, University of Padua, Italy.
出版信息
Neuropeptides. 1991 Jun;19(2):73-6. doi: 10.1016/0143-4179(91)90135-6.
Polypeptide YY (PYY), a 36-amino-acid peptide contained in high concentration in the chromaffin granules of adrenal medullary cells, significantly raised aldosterone (but not corticosterone) plasma level, when acutely administered intraperitoneum to rats at a dose of 25 microM.kg-1. Conversely, the exposure to PYY (10(-6) M) notably and specifically depressed both basal and ACTH-stimulated production of 18-hydroxylated steroids (aldosterone, 18-hydroxy-corticosterone and 180H-DOC) by isolated rat zona glomerulosa cells. The discrepancy between in vivo and in vitro results is tentatively explained by assuming that the direct inhibitory effect of PYY on aldosterone secretion by rat zona glomerulosa is masked in vivo by the interference of this peptide with one or more of the various factors that are involved in the multifactorial regulation of zona glomerulosa function.
多肽YY（PYY）是一种由36个氨基酸组成的肽，在肾上腺髓质细胞的嗜铬颗粒中高浓度存在。当以25微摩尔/千克的剂量急性腹腔注射给大鼠时，它能显著提高血浆醛固酮（但不包括皮质酮）水平。相反，将大鼠肾小球旁细胞暴露于10⁻⁶摩尔/升的PYY中，能显著且特异性地抑制基础状态下以及促肾上腺皮质激素刺激下的18-羟化类固醇（醛固酮、18-羟皮质酮和180H-DOC）的产生。体内和体外实验结果之间的差异，初步解释为假定PYY对大鼠肾小球旁细胞醛固酮分泌的直接抑制作用，在体内被该肽对参与肾小球旁细胞功能多因素调节的一种或多种不同因素的干扰所掩盖。
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