P物质对大鼠肾上腺球状带的体内作用。

Effects of substance P on the rat adrenal zona glomerulosa in vivo.

作者信息

Nussdorfer G G, Malendowicz L K, Belloni A S, Mazzocchi G, Rebuffat P

机构信息

Department of Anatomy, University of Padua, Italy.

出版信息

Peptides. 1988 Sep-Oct;9(5):1145-9. doi: 10.1016/0196-9781(88)90102-7.

DOI:10.1016/0196-9781(88)90102-7

PMID:2469063

Abstract

Substance P (SP) acutely enhanced the plasma concentration of aldosterone in rats whose hypothalamo-hypophyseal-adrenal axis and renin-angiotensin system were pharmacologically interrupted. The maximal response was obtained with a dose of 100 micrograms/kg. A prolonged (7 days) subcutaneous infusion with SP (50 micrograms/kg/hr) caused a notable hypertrophy of zona glomerulosa cells associated with significant rises in both basal and angiotensin-stimulated plasma levels of aldosterone. Zona fasciculata and the blood concentration of corticosterone were not affected. These findings suggest that SP is specifically involved in the stimulation of the growth and secretory activity of the rat zona glomerulosa.

摘要

在其下丘脑 - 垂体 - 肾上腺轴和肾素 - 血管紧张素系统被药物阻断的大鼠中，P物质（SP）能急性提高醛固酮的血浆浓度。剂量为100微克/千克时可获得最大反应。用SP（50微克/千克/小时）进行为期7天的皮下输注，会导致肾小球带细胞显著肥大，同时醛固酮的基础血浆水平和血管紧张素刺激的血浆水平均显著升高。束状带和皮质酮的血浓度未受影响。这些发现表明，SP特别参与刺激大鼠肾小球带的生长和分泌活动。