Sheremata W, Colby S, Karkhanis Y, Eylar E H
Can J Neurol Sci. 1975 May;2(2):87-90. doi: 10.1017/s0317167100020059.
Lymphocytes of 29 subjects were assayed for MIF production in response to P2 peripheral nerve protein, crude human peripheral nerve and human central nervous system Al basic myelin protein. Seven were performed in normal control subjects, 12 in Guillain-Barre patients (GB), 5 with other polyneuropathies and 5 in patients with multiple sclerosis (MS). Only GB patients with acute illness produced MIF in response to neuritogenic P2 protein and crude human nerve. Two MS patients in the acute phase of an exacerbation and one GB patient produced MIF in Response to Al protein. The results of this study demonstrate cellular hypersensitivity to a neuritogenic consituent in peripheral nervous tissue and support the concept that this may be important in the pathogenesis of GB.
对29名受试者的淋巴细胞进行检测，以观察其对P2周围神经蛋白、粗制人周围神经和人中枢神经系统碱性髓鞘蛋白产生迁移抑制因子（MIF）的反应。对7名正常对照受试者、12名格林-巴利综合征（GB）患者、5名患有其他多发性神经病的患者和5名多发性硬化症（MS）患者进行了检测。只有急性病的GB患者对致神经炎的P2蛋白和粗制人神经产生MIF。两名处于病情加重急性期的MS患者和一名GB患者对Al蛋白产生MIF。本研究结果表明细胞对周围神经组织中的一种致神经炎成分存在超敏反应，并支持这可能在GB发病机制中起重要作用的观点。
