Schmitt D L, Johnson D W, Henderson F W
Frank Porter Graham Child Development Center, University of North Carolina, Chapel Hill 27599-8180.
Pediatr Infect Dis J. 1991 Oct;10(10):729-34. doi: 10.1097/00006454-199110000-00002.
To characterize patterns of herpes simplex virus type 1 infection, illness and transmission among children in group day care, the data for 115 children who had been followed longitudinally from early infancy in a research day care center were examined. By 5 years of age 37% of study children had evidence of herpes simplex virus type 1 infection as demonstrated by virus isolation and/or seroconversion. The incidence of infection was highest among children 1 to 2 years old. Four small clusters of primary infections were observed over the 12-year study period but no cluster involved more than 6 children. Fifty-five percent of primary infections occurred during these small outbreaks; the remainder were sporadic. Gingivostomatitis was observed in 26% of children with primary culture-proved infections; no child with infection identified solely by serologic means had a history of gingivostomatitis. The occurrence of gingivostomatitis did not appear to be associated with increased transmission of herpes simplex virus type 1 infection in this day-care setting.
为了描述单纯疱疹病毒1型在日托中心儿童中的感染、发病及传播模式，我们检查了在一个研究性日托中心从婴儿早期开始纵向跟踪的115名儿童的数据。到5岁时，37%的研究儿童有单纯疱疹病毒1型感染的证据，这通过病毒分离和/或血清转化得以证实。感染发生率在1至2岁的儿童中最高。在12年的研究期间观察到4个原发性感染的小聚集群，但没有一个聚集群涉及超过6名儿童。55%的原发性感染发生在这些小暴发期间；其余为散发性感染。在26%经培养证实为原发性感染的儿童中观察到龈口炎；仅通过血清学方法确诊感染的儿童均无龈口炎病史。在这个日托环境中，龈口炎的发生似乎与单纯疱疹病毒1型感染传播增加无关。
