Manzella J P, McConville J H, Valenti W, Menegus M A, Swierkosz E M, Arens M
JAMA. 1984 Oct 19;252(15):2019-22.
An outbreak of herpes simplex virus (HSV) type I gingivostomatitis occurred in a dental hygiene practice in November 1981. An epidemiologic investigation disclosed that 20 of 46 patients seen by the dental hygienist during a four-day period had this illness, whereas none of 26 patients seen by the dentist alone became ill. One day after the outbreak, the hygienist was found to have a herpetic whitlow. Identical endonuclease restriction enzyme type I HSV was isolated from the left index finger of the hygienist and from nine of 16 patients. The nine patients with positive cultures all had at least a fourfold increase in complement fixing antibody titer. A similar significant increase in titer indicated another seven cases.
1981年11月，一家口腔卫生诊所爆发了I型单纯疱疹病毒（HSV）引起的龈口炎。一项流行病学调查显示，在四天时间里，口腔保健员接诊的46名患者中有20人患了这种疾病，而仅由牙医接诊的26名患者中无人患病。疫情爆发一天后，发现该口腔保健员患有疱疹性瘭疽。从该口腔保健员的左手食指以及16名患者中的9人体内分离出了相同的I型内切酶限制性酶切图谱的HSV。9名培养结果呈阳性的患者补体结合抗体效价均至少升高了四倍。效价有类似显著升高的情况表明还有另外7例病例。
