Martin D R, Brown C G, Dzwonczyk R
Department of Emergency Medicine, Ohio State University, Columbus 43210-1228.
Resuscitation. 1991 Aug;22(1):85-91. doi: 10.1016/0300-9572(91)90067-9.
Recent studies in swine have suggested that estimating the duration of ventricular fibrillation (VF) could have important implications regarding the selection of the best therapeutic intervention during cardiopulmonary resuscitation (CPR). Successful defibrillation resulting in a pulsatile rhythm is more likely with VF of short duration, whereas VF of longer duration may require interventions designed to augment myocardial blood flow prior to defibrillation. Duration of VF has been estimated in a swine model by modelling the median frequency (FM) of the VF ECG signal. The purpose of this study was to characterize the time course of the FM ECG signal in humans during VF and compare the characteristics of the human VF ECG signal to that previously described in swine. Seven two-channel human VF ECG recordings were analyzed via fast Fourier transformation. The FM was extracted from each four-second segment of the recordings and plotted versus time. The FM in humans followed a repeatable time course during VF. The human data revealed an FM which had two peaks with subsequent gradual decline. The data in swine revealed an FM during VF which decreased initially then increased to a peak followed by a gradual decline. Our preliminary results demonstrate that a characteristic median frequency exists in humans which could be used to estimate the duration of VF.
近期在猪身上开展的研究表明，估计心室颤动（VF）的持续时间对于在心肺复苏（CPR）期间选择最佳治疗干预措施可能具有重要意义。短时间的VF更有可能成功除颤并恢复搏动节律，而长时间的VF可能需要在除颤前采取旨在增加心肌血流的干预措施。在猪模型中，通过对VF心电图信号的中位频率（FM）进行建模来估计VF的持续时间。本研究的目的是描述人类VF期间FM心电图信号的时间进程，并将人类VF心电图信号的特征与先前在猪身上描述的特征进行比较。通过快速傅里叶变换分析了七份双通道人类VF心电图记录。从记录的每四秒片段中提取FM并绘制其随时间的变化。人类的FM在VF期间遵循可重复的时间进程。人类数据显示FM有两个峰值，随后逐渐下降。猪的数据显示VF期间的FM最初下降，然后上升至峰值，随后逐渐下降。我们的初步结果表明，人类存在可用于估计VF持续时间的特征性中位频率。
