Landmark K, Tellnes G, Fagerthun H E, Larsen S
Medisinsk klinikk, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1991 Oct 30;111(26):3176-9.
367 patients with mild-moderate hypertension were included in a multicentre study for the purpose of examining the antihypertensive effect of six weeks of treatment with the ACE-inhibitor lisinopril 10 and 20 mg once daily. Both low-dose and high-dose lisinopril significantly reduced sitting and standing blood pressure values. The fall in blood pressure in the sitting position was slightly but significantly greater among the high-dose group compared with the low-dose group (a 3 mm Hg fall difference in systolic values and a 1 mm Hg fall in diastolic values). No such differences were found in the standing position. Heart rate remained unchanged during lisinopril treatment. Episodes of possible first dose hypotension were reported in six patients. Approximately 90% of the patients in both groups were classified as responders according to defined criteria. The frequency of side-effects was low, and was equal in both treatment groups. An evaluation of reduction in blood pressure, and of response rate and side-effects suggests that an initial dose of 10 mg lisinopril once daily is sufficient, and that this dosage will control blood pressure in the majority of patients.
367例轻中度高血压患者被纳入一项多中心研究，目的是检验每天一次服用10毫克和20毫克血管紧张素转换酶抑制剂赖诺普利进行六周治疗的降压效果。低剂量和高剂量赖诺普利均显著降低了坐位和站位血压值。与低剂量组相比，高剂量组坐位血压下降幅度虽小但显著更大（收缩压下降幅度相差3毫米汞柱，舒张压下降1毫米汞柱）。站位未发现此类差异。赖诺普利治疗期间心率保持不变。6例患者报告了可能的首剂低血压发作。根据既定标准，两组中约90%的患者被归类为反应者。副作用发生率较低，且两个治疗组相同。对血压降低、反应率和副作用的评估表明，每天一次10毫克赖诺普利的初始剂量就足够了，并且该剂量将控制大多数患者的血压。
