Oelkers W, Schöneshöfer M, Schultze G, Brown J J, Fraser R, Morton J J, Lever A F, Robertson J I
Circ Res. 1975 Jun;36(6 Suppl 1):49-56. doi: 10.1161/01.res.36.6.49.
The effect of incremental infusions of isoleucine-5-angiotensin II on blood pressure and plasma aldosterone concentrations was studied in normal man before and after 66 hours of intravenous infusion of angiotensin II at 2 ng kg-1 min-1, sodium and potassium balance being kept roughly constant throughout. Plasma sodium and ACTH concentrations were unaltered, but plasma potassium and magnesium levels and basal plasma cortisol fell slightly after prolonged angiotensin administration. During the prolonged angiotensin infusion plasma renin activity was suppressed, and there was a sustained elevation of arterial pressure and plasma aldosterone concentration. Aldosterone excretion, while clearly increased, showed a regular circadian rhythm, with peak values in the early morning. The angiotensin II-pressor relationship was not significantly changed after the prolonged infusion of angiotensin II, while the angiotensin II-aldosterone dose-response curve was steeper than in the basal state but not identical with that of sodium depletion. No differences were observed in the pressor or aldosterone-stimulant effects of the isoleucine-5 and valine-5 forms of angiotensin II. A trophic effect of angiotensin II on the adrenal cortex may provide a partial explanation for the enhanced response of aldosterone to angiotensin II in sodium depleted man.
在正常男性中，研究了在以2 ng kg-1 min-1的速率静脉输注血管紧张素II 66小时前后，递增输注异亮氨酸-5-血管紧张素II对血压和血浆醛固酮浓度的影响，在此过程中钠和钾平衡大致保持恒定。血浆钠和促肾上腺皮质激素浓度未改变，但长时间给予血管紧张素后，血浆钾和镁水平以及基础血浆皮质醇略有下降。在长时间输注血管紧张素期间，血浆肾素活性受到抑制，动脉压和血浆醛固酮浓度持续升高。醛固酮排泄虽明显增加，但呈现出规律的昼夜节律，清晨达到峰值。长时间输注血管紧张素II后，血管紧张素II-升压关系无显著变化，而血管紧张素II-醛固酮剂量反应曲线比基础状态时更陡峭，但与钠耗竭时不同。异亮氨酸-5和缬氨酸-5形式的血管紧张素II在升压或刺激醛固酮方面未观察到差异。血管紧张素II对肾上腺皮质的营养作用可能部分解释了钠耗竭男性中醛固酮对血管紧张素II反应增强的现象。
