Gianotti R, Alessi E, Cavicchini S, Berti E
First Clinic of Dermatology, University of Milan, Italy.
Am J Dermatopathol. 1991 Oct;13(5):503-8. doi: 10.1097/00000372-199110000-00013.
Pleomorphic peripheral T-cell lymphomas (PPTL) arising primarily in the skin are uncommon. The observation of pleomorphic T-cell lymphoma composed of 100% CD30+ cells is rare. We report the case of a woman in whom such a tumor manifested itself with a single cutaneous lesion. It was composed of medium to large cells expressing markers of helper/inducer T-lymphocytes, as well as activation (CD30) and proliferation antigens (Ki-67), but not the CD25 activation antigen. The lesion was excised and the patient is alive and disease free 2 years after the diagnosis. This case confirms previous reports about the favorable course of some cutaneous pleomorphic lymphomas, and shows that the activation antigen expression and proliferation antigen (Ki-67) expression do not seem to worsen the prognosis.
主要发生于皮肤的多形性外周T细胞淋巴瘤（PPTL）并不常见。由100% CD30+细胞组成的多形性T细胞淋巴瘤的情况罕见。我们报告了一例这样的肿瘤以单个皮肤损害表现的女性病例。它由表达辅助/诱导性T淋巴细胞标志物以及激活抗原（CD30）和增殖抗原（Ki-67）的中到大细胞组成，但不表达CD25激活抗原。该损害被切除，诊断后2年患者存活且无疾病。此病例证实了先前关于某些皮肤多形性淋巴瘤预后良好的报道，并表明激活抗原表达和增殖抗原（Ki-67）表达似乎并未使预后恶化。
