甲状腺素对大鼠肝脏线粒体心磷脂合酶活性的影响。
Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver.
作者信息
Hostetler K Y
机构信息
Department of Medicine, University of California, San Diego.
出版信息
Biochim Biophys Acta. 1991 Oct 15;1086(1):139-40. doi: 10.1016/0005-2760(91)90165-e.
PMID:1659453
Abstract
Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250 micrograms/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase.
摘要
心磷脂是一种主要的线粒体膜脂，在线粒体功能中起着至关重要的作用。本研究检测了甲状腺素对肝脏线粒体心磷脂合酶活性的影响。用甲状腺素（250微克/100克）处理5天，可使心磷脂合酶活性提高52%。心磷脂的线粒体水平似乎部分受甲状腺激素对心磷脂合酶活性影响的调节。
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