[Effect of thyroid hormones on the physico-chemical properties of lipids in the liver mitochondria of rats].

The administration of thyroxine to rats (300 micrograms per 100 g of body mass intraperitoneally) resulted in a decrease in the content of cardiolipin, cholesterol and an increase in lysophosphatidylethanolamine in rat mitochondria as compared to normal in 48 hours. During the registration of spin-labeled mitochondrial lipids using the EPR method thyroid-related changes in the regulation parameter on Arrenius' charts were detected suggesting the regulation of the physical state of mitochondrial lipids by thyroid hormones. It was assumed that the observed hormone-related modifications of the physicochemical state of mitochondrial lipids illustrated the membranotropic mechanism of the regulation of mitochondrial functions by thyroid hormones.