Higgs Brandon W, Elashoff Michael, Richman Sam, Barci Beata
Elashoff Consulting LLC, Germantown, MD 20876, USA.
BMC Genomics. 2006 Apr 4;7:70. doi: 10.1186/1471-2164-7-70.
The Stanley Medical Research Institute online genomics database (SMRIDB) is a comprehensive web-based system for understanding the genetic effects of human brain disease (i.e. bipolar, schizophrenia, and depression). This database contains fully annotated clinical metadata and gene expression patterns generated within 12 controlled studies across 6 different microarray platforms.
A thorough collection of gene expression summaries are provided, inclusive of patient demographics, disease subclasses, regulated biological pathways, and functional classifications.
The combination of database content, structure, and query speed offers researchers an efficient tool for data mining of brain disease complete with information such as: cross-platform comparisons, biomarkers elucidation for target discovery, and lifestyle/demographic associations to brain diseases.
斯坦利医学研究所在线基因组数据库(SMRIDB)是一个基于网络的综合系统,用于了解人类脑部疾病(即双相情感障碍、精神分裂症和抑郁症)的遗传效应。该数据库包含在6个不同微阵列平台上进行的12项对照研究中生成的经过充分注释的临床元数据和基因表达模式。
提供了全面的基因表达总结,包括患者人口统计学信息、疾病亚类、调控的生物途径和功能分类。
数据库的内容、结构和查询速度相结合,为研究人员提供了一个高效的数据挖掘工具,可用于挖掘脑部疾病的数据,包括:跨平台比较、用于靶点发现的生物标志物阐明,以及生活方式/人口统计学与脑部疾病的关联。