Higuchi Terumi, Matsukawa Yoshihiro, Okada Kazuyoshi, Oikawa Osamu, Yamazaki Toshio, Ohnishi Yoshihiko, Fujita Takayuki, Fukuda Noboru, Soma Masayoshi, Matsumoto Koichi
Division of Nephrology and Endocrinology, Department of Medicine, Nihon University School of Medicine, Oyaguchi-Kamimachi, Tokyo.
Intern Med. 2006;45(5):271-3. doi: 10.2169/internalmedicine.45.1541. Epub 2006 Apr 3.
We have encountered five hemodialysis patients who had received enteral nutrition and recovered from erythropoietin-resistant anemia with neutropenia after the correction of copper deficiency. We reduced the required doses of recombinant human erythropoietin (rHuEPO) to maintain the target hematocrit levels and three patients were finally weaned from the rHuEPO therapy. Thus, copper deficiency is involved in erythropoietin-resistant anemia in hemodialysis patients.
我们遇到了5名接受肠内营养的血液透析患者，他们在纠正铜缺乏后，从伴有中性粒细胞减少的促红细胞生成素抵抗性贫血中康复。我们减少了重组人促红细胞生成素（rHuEPO）的所需剂量以维持目标血细胞比容水平，最终有3名患者停止了rHuEPO治疗。因此，铜缺乏与血液透析患者的促红细胞生成素抵抗性贫血有关。
