Kamiya Hiroyuki, Shinoda Kinya, Kobayashi Nobuyuki, Kudo Koichiro, Nomura Tomokiyo, Morita Takatomo, Fujii Takeshi
Department of Respiratory Medicine, International Medical Center of Japan, Toyama, Tokyo.
Intern Med. 2006;45(5):275-8. doi: 10.2169/internalmedicine.45.1136. Epub 2006 Apr 3.
A 41-year-old woman with a history of epilepsy was referred for multiple nodular ground-glass opacities on a chest computed tomography (CT) scan. They were initially suspected of representing atypical adenomatous hyperplasia or well-differentiated adenocarcinoma. However, the subsequent brain CT and magnetic resonance imaging (MRI) scans revealed a coarse nodular calcification and cortical tubers. A subungual fibroma was also noted. Histological examination of a video-assisted thoracoscopic lung biopsy specimen disclosed multiple nodules of type II pneumocyte hyperplasia with septal thickening. Based on all of these findings taken together, a diagnosis of tuberous sclerosis complex with multifocal micronodular pneumocyte hyperplasia (MMPH) was made.
一名有癫痫病史的41岁女性因胸部计算机断层扫描（CT）发现多个结节状磨玻璃影而前来就诊。最初怀疑这些结节代表非典型腺瘤样增生或高分化腺癌。然而，随后的脑部CT和磁共振成像（MRI）扫描显示有粗大的结节状钙化和皮质结节。还发现了甲下纤维瘤。电视辅助胸腔镜肺活检标本的组织学检查显示为II型肺泡上皮细胞增生伴间隔增厚的多个结节。综合所有这些发现，诊断为结节性硬化症合并多灶性微小结节性肺泡上皮细胞增生（MMPH）。
