Taniguchi Natsuko, Konno Satoshi, Nasuhara Yasuyuki, Matsuno Yoshihiro, Oka Teruaki, Nishimura Masaharu
"First Department of Medicine, Hokkaido University School of Medicine.
Nihon Kokyuki Gakkai Zasshi. 2011 May;49(5):355-9.
A 30-year-old woman was referred because of multiple ground-glass opacities (GGOs) on chest CT examination. Lung biopsy was performed. Histologically, multifocal well-demarcated nodular lesions comprising proliferation of type II pneumocytes with mild fibrous thickening of the alveolar septa were observed in the lung tissue. We made a histopathologic diagnosis of multifocal micronodular pneumocyte hyperplasia (MMPH). Neither the clinical findings nor the family history of the patient suggested tuberous sclerosis (TSC). MMPH is a pulmonary manifestation of tuberous sclerosis, together with lymphangioleiomyomatosis (LAM). MMPH should be considered as a differential diagnosis of multiple GGOs in the lung even when findings of TSC and LAM are not recognized.
一名30岁女性因胸部CT检查发现多发磨玻璃影（GGO）而前来就诊。进行了肺活检。组织学检查显示，肺组织中可见多灶性边界清晰的结节性病变，由II型肺泡上皮细胞增生和肺泡间隔轻度纤维增厚组成。我们做出了多灶性微小结节性肺细胞增生（MMPH）的组织病理学诊断。患者的临床表现和家族史均未提示结节性硬化症（TSC）。MMPH是结节性硬化症的肺部表现之一，与淋巴管平滑肌瘤病（LAM）一样。即使未发现TSC和LAM的表现，MMPH也应被视为肺部多发GGO的鉴别诊断之一。
