Bouillon L E, Flynn M G, Lambert C P, Fahlman M, Braun W A, Choi D
University of Findlay, Findlay, OH 45840, USA.
J Sports Med Phys Fitness. 2006 Mar;46(1):143-51.
The purpose of this study was to examine whether training status and plasma hormones (estradiol--E2, progesterone--P, luteinizing hormone--LH, and follicle-stimulating hormone--FSH) have an effect on selected immune indexes during or following an acute bout of exercise.
Seven female triathletes (TRI) and 7 recreationally active (REC) females were randomly assigned to rest (RE) and exercise (EX) trials during the late-follicular menstrual phase (LF). The EX was 1 hour of cycling at 63.1+/-6% VO2peak (TRI) and 61+/-5.1% VO2peak (REC) and RE was 1 hour of sitting. Blood was drawn for both trials at baseline (0H), 1 hour (1H), and at 3 hours (3H).
Positive correlations were found between E2 and CD19+ cells for both groups as well as P and CD8+ cells for the REC group. E2 increased during EX and returned to baseline at 3HEX for both groups, however, LH remained elevated at 3HEX for REC. There were significant exercise time effects for CD3+, CD4+, CD8+, and CD3- CD16+ CD56+ cells. The NCMC and 1:1 were elevated at 1HEX for both groups and returned to baseline by 3HEX. During RE, CD3- CD16+ CD56+ cell numbers for both groups and NCMC for REC remained elevated at 3HRE.
E2 and P correlated with CD19+ and CD8+ cells, respectively. Although there were transient exercise-induced changes in immune indexes and E2 and LH, with LH remaining elevated at 3HEX for REC, both training groups elicited similar responses for plasma hormones, lymphocyte subpopulations, and NCMC.
本研究旨在探讨训练状态和血浆激素（雌二醇-E2、孕酮-P、促黄体生成素-LH和促卵泡激素-FSH）在急性运动期间或之后是否对选定的免疫指标有影响。
7名女性铁人三项运动员（TRI）和7名休闲活跃（REC）女性在卵泡期后期（LF）被随机分配到休息（RE）和运动（EX）试验组。EX组进行1小时的骑行，运动强度为最大摄氧量（VO2peak）的63.1±6%（TRI组）和61±5.1%（REC组），RE组静坐1小时。在基线（0小时）、1小时（1H）和3小时（3H）对两组进行采血。
两组的E2与CD19+细胞之间以及REC组的P与CD8+细胞之间均存在正相关。两组在运动期间E2均升高，并在运动后3小时（3HEX）恢复到基线水平，然而，REC组在运动后3小时LH仍保持升高。CD3+、CD4+、CD8+和CD3-CD16+CD56+细胞有显著的运动时间效应。两组在运动后1小时（1HEX）自然杀伤细胞介导的细胞毒性（NCMC）和1:1均升高，并在运动后3小时恢复到基线水平。在休息期间，两组的CD3-CD16+CD56+细胞数量以及REC组的NCMC在休息后3小时（3HRE）仍保持升高。
E2和P分别与CD19+和CD8+细胞相关。尽管运动引起免疫指标、E2和LH出现短暂变化，REC组在运动后3小时LH仍保持升高，但两个训练组在血浆激素、淋巴细胞亚群和NCMC方面引发了相似的反应。
