Flynn M G, Fahlman M, Braun W A, Lambert C P, Bouillon L E, Brolinson P G, Armstrong C W
Wastl Human Performance Laboratory, Purdue University, West Lafayette, Indiana 47907, USA.
J Appl Physiol (1985). 1999 Jun;86(6):1905-13. doi: 10.1152/jappl.1999.86.6.1905.
Women aged 67-84 yr were randomly assigned to either resistance exercise (RE, n = 15) or control group (C, n = 14). RE group completed 10 wk of resistance training, whereas C group maintained normal activity. Blood samples were obtained from the RE group (at the same time points as for resting C) at rest, immediately after resistance exercise, and 2 h after exercise before (week 0) and after (week 10) training. Mononuclear cell (CD3+, CD3+CD4+, CD3+CD8+, CD19+, and CD3-CD16+CD56+) number, lymphocyte proliferative (LP) response to mitogen, natural cell-mediated cytotoxicity (NCMC), and serum cortisol levels were determined. Strength increased significantly in RE subjects (%change 8-repetition maximum = 148%). No significant group, exercise time, or training effects were found for CD3+, CD3+CD4+, or CD3+CD8+ cells, but there was a significant exercise time effect for CD3-CD16+CD56+ cells. LP response was not different between groups, across exercise time, or after training. NCMC was increased immediately after exercise for RE subjects at week 0 and for RE and C groups at week 10. The week 0 and week 10 NCMC values were above baseline for both RE and C groups 2 h after exercise. In conclusion, acute resistance exercise did not result in postexercise suppression of NCMC or LP, and 10 wk of resistance training did not influence resting immune measures in women aged 67-84 yr.
67至84岁的女性被随机分为抗阻运动组（RE，n = 15）或对照组（C，n = 14）。抗阻运动组完成了10周的抗阻训练，而对照组保持正常活动。在训练前（第0周）和训练后（第10周），于静息状态、抗阻运动结束后即刻以及运动后2小时（与静息对照组相同时间点）采集抗阻运动组的血样。测定单核细胞（CD3⁺、CD3⁺CD4⁺、CD3⁺CD8⁺、CD19⁺和CD3⁻CD16⁺CD56⁺）数量、淋巴细胞对丝裂原的增殖（LP）反应、自然细胞介导的细胞毒性（NCMC）以及血清皮质醇水平。抗阻运动组受试者的力量显著增加（8次重复最大值变化百分比 = 148%）。对于CD3⁺、CD3⁺CD4⁺或CD3⁺CD8⁺细胞，未发现显著的组间、运动时间或训练效应，但对于CD3⁻CD16⁺CD56⁺细胞存在显著的运动时间效应。组间、整个运动时间或训练后，LP反应无差异。在第0周，抗阻运动组受试者运动后即刻NCMC增加，在第10周，抗阻运动组和对照组运动后即刻NCMC均增加。运动后2小时，第0周和第10周抗阻运动组和对照组的NCMC值均高于基线水平。总之，急性抗阻运动并未导致运动后NCMC或LP的抑制，10周的抗阻训练对67至84岁女性的静息免疫指标无影响。
