阿尔茨海默病患者促肾上腺皮质激素和皮质醇的分泌
ACTH and cortisol secretion in patients with Alzheimer's disease.
作者信息
Franceschi M, Airaghi L, Gramigna C, Truci G, Manfredi M G, Canal N, Catania A
机构信息
Scientific Institute S Raffaele, Neurology Department, Milan, Italy.
出版信息
J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):836-7. doi: 10.1136/jnnp.54.9.836.
Abstract
The "glucocorticoid cascade hypothesis" for pathological ageing of the brain is supported by strong experimental data, but the clinical correlates are far less clear. The basal ACTH and cortisol secretion have been studied before and after the dexamethasone suppression test in patients in the early stages of clinically probable Alzheimer's disease and in controls, and the results were all normal. These findings do not support the hypothesis that the pathological brain ageing of Alzheimer's type is caused by hyperactivity of the pituitary-adrenal axis.
摘要
大脑病理性衰老的“糖皮质激素级联假说”得到了有力实验数据的支持，但临床相关性却远不那么明确。在临床可能为阿尔茨海默病早期的患者及对照组中，对地塞米松抑制试验前后的基础促肾上腺皮质激素（ACTH）和皮质醇分泌进行了研究，结果均正常。这些发现不支持阿尔茨海默病型大脑病理性衰老由垂体 - 肾上腺轴功能亢进引起这一假说。
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本文引用的文献
1
Participation of the dorsal hippocampus in the glucocorticoid feedback effect on adrenocortical activity.背侧海马体在糖皮质激素对肾上腺皮质活动的反馈作用中的参与。
Neuroendocrinology. 1980;30(1):52-5. doi: 10.1159/000122974.
2
Dexamethasone suppression test and cortisol circadian rhythm in primary degenerative dementia.
Am J Psychiatry. 1982 Nov;139(11):1468-71. doi: 10.1176/ajp.139.11.1468.
3
Effects of chronic medical illness and dementia on the dexamethasone suppression test.慢性疾病和痴呆对地塞米松抑制试验的影响。
J Am Geriatr Soc. 1983 May;31(5):269-71. doi: 10.1111/j.1532-5415.1983.tb04869.x.
4
Dexamethasone suppression test and serum prolactin in dementia disorders.痴呆症中的地塞米松抑制试验和血清催乳素
Br J Psychiatry. 1983 Sep;143:277-81. doi: 10.1192/bjp.143.3.277.
5
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.阿尔茨海默病的临床诊断：美国国立神经疾病与中风研究所-阿尔茨海默病及相关疾病协会工作组在卫生与公众服务部阿尔茨海默病特别工作组主持下的报告。
Neurology. 1984 Jul;34(7):939-44. doi: 10.1212/wnl.34.7.939.
6
Does severity of dementia modulate response to dexamethasone in individuals with primary degenerative dementia?在原发性退行性痴呆患者中，痴呆的严重程度是否会调节对地塞米松的反应？
Biol Psychiatry. 1984 Oct;19(10):1481-7.
7
Tests of hypothalamic-pituitary-adrenal function in man.人体下丘脑 - 垂体 - 肾上腺功能测试。
Q J Med. 1969 Oct;38(152):475-91.
8
Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications.糖皮质激素会增强神经元的缺血性损伤：治疗意义。
Science. 1985 Sep 27;229(4720):1397-400. doi: 10.1126/science.4035356.
9
Dexamethasone suppression in dementia, depression, and normal aging.痴呆、抑郁和正常衰老中的地塞米松抑制。
Am J Psychiatry. 1986 Apr;143(4):452-6. doi: 10.1176/ajp.143.4.452.
10
The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis.应激与衰老的神经内分泌学：糖皮质激素级联假说
Endocr Rev. 1986 Aug;7(3):284-301. doi: 10.1210/edrv-7-3-284.
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