Ariyoshi Yasunori, Shimahara Masashi
Department of Oral Surgery, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan.
Oncol Rep. 2006 May;15(5):1339-43.
The purpose of this study was to evaluate the effectiveness of dynamic contrast-enhanced MRI (DC-MRI) for assessing the pattern of invasion of tongue carcinomas. We studied 20 cases of squamous cell carcinoma of the tongue that showed peripheral enhancement patterns on DC-MRI. The diameter of each tumor was >2.0 cm and no apparent artifacts were seen. The signal enhancement to noise ratio (SE/N) of the regions of interest, which were located in the central and peripheral regions of the tumor, were measured using DC-MRI, while maximum SE/N, %-wash out, and the ascending rate of SE/N were also calculated. The histopathological pattern of invasion was assessed in each case and used to classify them into clear (13 cases) and diffuse (7 cases) groups, after which the 4 parameters were compared between the 2 groups. The ascending rate of SE/N in the peripheral region was significantly lower in the diffuse group (p=0.047). There were no other significant differences between the 2 groups for any parameter in either tumor region. These results suggest that DC-MRI is able to show the histopathological pattern of invasion into surrounding structures.
本研究的目的是评估动态对比增强磁共振成像（DC-MRI）在评估舌癌浸润模式方面的有效性。我们研究了20例在DC-MRI上显示周边强化模式的舌鳞状细胞癌病例。每个肿瘤的直径均大于2.0 cm，且未见明显伪影。使用DC-MRI测量位于肿瘤中央和周边区域的感兴趣区域的信号增强噪声比（SE/N），同时还计算最大SE/N、洗脱百分比和SE/N的上升速率。评估每个病例的组织病理学浸润模式，并将其分为清晰（13例）和弥漫（7例）两组，然后比较两组之间的4个参数。弥漫组周边区域SE/N的上升速率显著较低（p=0.047）。在任一肿瘤区域，两组之间的任何参数均无其他显著差异。这些结果表明，DC-MRI能够显示向周围结构的组织病理学浸润模式。
