Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No.639 Zhizaoju Road, Shanghai, China.
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Eur Radiol. 2022 Jan;32(1):254-261. doi: 10.1007/s00330-021-08148-6. Epub 2021 Jul 13.
To compare the correlation of depth of invasion (DOI) measured on multiple magnetic resonance imaging (MRI) sequences and pathological DOI, in order to determine the optimal MRI sequence for measurement.
A total of 122 oral tongue squamous cell carcinoma (OTSCC) patients were retrospectively analyzed, who had received preoperative MRI and surgical resection. DOIs measured on fat-suppressed T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), dynamic enhanced-T1 high-resolution insotropic volume examination (e-THRIVE), and contrast-enhanced fat-suppressed T1WI (CE-T1WI) were respectively compared to those measured in pathologic specimens. The cutoff value of the best correlated MRI sequence was determined, and the T staging accuracy of MRI-derived DOI was evaluated.
DOI derived from e-THRIVE showed the best correlation (r = 0.936, p < 0.001) with pathological DOI. The area under the curve values of MRI-derived DOI distinguishing T1 stage from T2 stage and distinguishing T2 stage from T3 stage were 0.969 and 0.974, respectively. The T staging criteria of MRI-derived DOI were 6.2 mm and 11.4 mm, with a staging accuracy of 86.9% compared to pathological DOI criteria of 5 mm and 10 mm.
E-THRIVE was the optimal MR sequence to measure the MR-derived DOI, and DOI derived from e-THRIVE could serve as a potential cut-off value as a clinical T staging indicator of OTSCC.
• Multiparametric MRI helps radiologists to assess the neoplasm invasion in patients with oral tongue squamous cell carcinoma. • Retrospective study indicated that measurement was most accurate on enhanced-T1 high-resolution insotropic volume examination dynamic contrast enhancement images. • T staging of oral tongue squamous cell carcinoma was accurate according to the dynamic contrast enhancement MRI-derived depth of invasion.
比较多序列磁共振成像（MRI）测量的浸润深度（DOI）与病理 DOI 的相关性，以确定最佳的 MRI 测量序列。
回顾性分析了 122 例接受术前 MRI 和手术切除的口腔舌鳞状细胞癌（OTSCC）患者。分别比较了脂肪抑制 T2 加权成像（T2WI）、弥散加权成像（DWI）、动态增强 T1 高分辨率各向同性容积检查（e-THRIVE）和对比增强脂肪抑制 T1WI（CE-T1WI）上测量的 DOI。确定最佳相关 MRI 序列的截止值，并评估 MRI 衍生 DOI 的 T 分期准确性。
e-THRIVE 衍生的 DOI 与病理 DOI 相关性最好（r = 0.936，p < 0.001）。MRI 衍生的 DOI 区分 T1 期和 T2 期以及区分 T2 期和 T3 期的曲线下面积值分别为 0.969 和 0.974。MRI 衍生的 DOI 的 T 分期标准为 6.2mm 和 11.4mm，与病理 DOI 标准的 5mm 和 10mm 相比，分期准确性为 86.9%。
e-THRIVE 是测量 MRI 衍生 DOI 的最佳 MR 序列，e-THRIVE 衍生的 DOI 可作为 OTSCC 临床 T 分期指标的潜在截止值。
